Article (Scientific journals)
Nitric oxide synthase inhibition lowers activity of neurons with meningeal input in the rat spinal trigeminal nucleus
De Col, R.; Koulchitsky, Stanislav; Messlinger, K. B.
2003In Neuroreport, 14 (2), p. 229-32
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Keywords :
Nitric oxide; Trigeminal nucleus; neuronal activity; headache
Abstract :
[en] Nitric oxide is thought to control transmitter release and neuronal activity in the spinal dorsal horn and the spinal trigeminal nucleus, where nociceptive information from extra- and intracranial tissues is processed. Extracellular impulse activity was recorded from neurons in the rat spinal trigeminal nucleus with afferent input from the cranial dura mater. In contrast to the inactive isomer D-NAME, infusion of the nitric oxide synthase inhibitor L-NAME (20 mg/kg) significantly reduced neuronal activity and increased systemic blood pressure. It is concluded that nitric oxide production contributes to the ongoing activity of sensitized neurons in the spinal trigeminal nucleus. The results suggest that nitric oxide may be involved in the generation and maintenance of primary headaches such as migraine.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
De Col, R.
Koulchitsky, Stanislav ;  Université de Liège > Département des sciences biomédicales et précliniques > Pharmacologie
Messlinger, K. B.
Language :
English
Title :
Nitric oxide synthase inhibition lowers activity of neurons with meningeal input in the rat spinal trigeminal nucleus
Publication date :
2003
Journal title :
Neuroreport
ISSN :
0959-4965
eISSN :
1473-558X
Publisher :
Lippincott Williams & Wilkins, London, United Kingdom
Volume :
14
Issue :
2
Pages :
229-32
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 August 2017

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