Tramadol plus metamizole combined or not with anti-inflammatory drugs is clinically effective for moderate to severe chronic pain treatment in cancer patients.
Flor, Patricia B.; Yazbek, Karina V. B.; Ida, Keilaet al.
2013 • In Veterinary Anaesthesia and Analgesia, 40 (3), p. 316-27
[en] OBJECTIVE: To test the effectiveness and safety of tramadol plus metamizole combined or not with a non-steroidal anti-inflammatory drug (NSAID) for treating moderate to severe chronic neoplastic pain in dogs, and its impact on quality of life (QL). STUDY DESIGN: Prospective, uncontrolled, open-label, clinical study. ANIMALS: Sixty nine client-owned dogs with multiple forms of cancer and visual analog scale (VAS) pain score >/= 40 after receiving NSAIDs for at least 7 days. METHODS: The MN group received metamizole + NSAID, MNT group received metamizole + NSAID + tramadol and MT group received metamizole + tramadol. Pain was scored by the 0 to 100 mm VAS (0 = no pain, 100 = worst pain) and analgesic therapy was considered effective if 25 mm differences in VAS scores were observed between day 0 and the follow ups. The QL was evaluated according to a 0 to 36 scoring method for dogs (0 = worst, 36 = best) and side effects were recorded. Data were registered at day 0 (baseline) and at the first and second follow ups (7 and 14 days after day 0, respectively). RESULTS: The MN group had less analgesia at day 7 (25%) and day 14 (42%) than MNT (59%, p = 0.0274; 76%, p = 0.0251, respectively) and MT groups (69%, p = 0.0151; 81%, p = 0.0341, respectively). The QL scores were lower in the MN group at the first (score 23) and second follow up (score 26) than in MNT (27, p = 0.0847; 30, p = 0.0002) and MT (28, p = 0.0384; 31, p = 0.0001) groups. Side effects were more commonly observed in the MN group (87%) than in MNT (24%, p < 0.0001) and MT groups (25%, p = 0.0003) at the first follow up. CONCLUSIONS AND CLINICAL RELEVANCE: Tramadol plus metamizole combined or not with NSAID were well tolerated and clinically effective to treat moderate to severe pain in dogs with cancer and improved QL.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Flor, Patricia B.
Yazbek, Karina V. B.
Ida, Keila ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires
Fantoni, Denise T.
Language :
English
Title :
Tramadol plus metamizole combined or not with anti-inflammatory drugs is clinically effective for moderate to severe chronic pain treatment in cancer patients.
Publication date :
2013
Journal title :
Veterinary Anaesthesia and Analgesia
ISSN :
1467-2987
eISSN :
1467-2995
Publisher :
Elsevier, New York, United States - New York
Volume :
40
Issue :
3
Pages :
316-27
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2013 The Authors. Veterinary Anaesthesia and Analgesia (c) 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.
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