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Recognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas; Blanpain, Manon; Van Egroo, Maxime et al.
2017BAPS 2017
 

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Keywords :
memory; recognition; hippocampus; hippocampal volume
Abstract :
[en] Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Method. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region. Discussion. In a late middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects.
Research center :
GIGA-CRC In Vivo Imaging, University of Liège
Disciplines :
Neurosciences & behavior
Author, co-author :
Narbutas, Justinas ;  Université de Liège > Centre de recherches du cyclotron
Blanpain, Manon ;  Université de Liège - ULiège > Master sc. psycho., à fin.
Van Egroo, Maxime ;  Université de Liège > Centre de recherches du cyclotron
Besson, Gabriel ;  Université de Liège > Centre de recherches du cyclotron
Schmidt, Christina  ;  Université de Liège > Département de Psychologie > Neuropsychologie
Gaggioni, Giulia ;  Université de Liège > Centre de recherches du cyclotron
Muto, Vincenzo  ;  Université de Liège > Centre de recherches du cyclotron
Salmon, Eric  ;  Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Vandewalle, Gilles  ;  Université de Liège > Centre de recherches du cyclotron
Bastin, Christine  ;  Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Collette, Fabienne  ;  Université de Liège > Département de Psychologie > Neuropsychologie
Language :
English
Title :
Recognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Publication date :
31 May 2017
Event name :
BAPS 2017
Event place :
Bruxelles, Belgium
Event date :
31 May 2017
Audience :
International
Name of the research project :
Cognitive Fitness in Aging
Funders :
ULg - Université de Liège [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FMRE - Fondation Médicale Reine Elisabeth [BE]
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since 05 July 2017

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