Article (Scientific journals)
Serum Creatinine: Not So Simple!
DELANAYE, Pierre; Cavalier, Etienne; Pottel, Hans
2017In Nephron journals, 136 (4), p. 302-308
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Keywords :
Glomerular filtration rate; Jaffe; Serum creatinine
Abstract :
[en] Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of serum creatinine, insisting on important concept such as reference intervals, standardization (and IDMS traceability), analytical interferences, analytical coefficient of variation (CV), biological CV and critical difference. Because the relationship between serum creatinine and glomerular filtration rate is hyperbolic, all these CVs will impact not only the precision of serum creatinine but still more the precision of different creatinine-based equations, especially in low or normal-low creatinine levels (or high or normal-high glomerular filtration rate range).
Disciplines :
Urology & nephrology
Laboratory medicine & medical technology
Author, co-author :
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie
Cavalier, Etienne  ;  Université de Liège > Département de pharmacie > Chimie médicale
Pottel, Hans
Language :
English
Title :
Serum Creatinine: Not So Simple!
Publication date :
2017
Journal title :
Nephron journals
ISSN :
1660-8151
eISSN :
2235-3186
Publisher :
Karger, Basel, Switzerland
Volume :
136
Issue :
4
Pages :
302-308
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2017 S. Karger AG, Basel.
Available on ORBi :
since 04 July 2017

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