Article (Scientific journals)
Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field
Cailletaud, Johan; De Bleye, Charlotte; Dumont, Elodie et al.
2018In Journal of Pharmaceutical and Biomedical Analysis, 147, p. 458-472
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Keywords :
Surface-Enhanced Raman Scattering; Pharmaceutical field; Quantitative determination; Method validation
Abstract :
[en] Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is more sensitive allowing its use for the detection and the quantification of low-dose substances contained in pharmaceutical samples. However, the analytical performance of SERS is limited due to the difficulty to implement a quantitative methodology correctly validated. Nevertheless, some studies reported the development of SERS quantitative methods especially in pharmaceutical approaches. In this context, this review presents the main concepts of the SERS technique. The different steps that need to be applied to develop a SERS quantitative method are also deeply described. The last part of the present manuscript gives a critical overview of the different SERS pharmaceutical applications that were developed for a non-exhaustive list of pharmaceutical compounds with the aim to highlights the validation criteria for each application.
Research center :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Cailletaud, Johan ;  Université de Liège > Département de pharmacie > Chimie analytique
De Bleye, Charlotte  ;  Université de Liège > Département de pharmacie > Département de pharmacie
Dumont, Elodie ;  Université de Liège > Département de pharmacie > Chimie analytique
Sacre, Pierre-Yves  ;  Université de Liège > Département de pharmacie > Chimie analytique
Netchacovitch, Lauranne ;  Université de Liège > Département de pharmacie > Chimie analytique
Gut, Yoann;  Technologie Servier
Boiret, Mathieu;  Horiba France
Ginot, Yves-Michel;  Technologie Servier
Hubert, Philippe  ;  Université de Liège > Département de pharmacie > Chimie analytique
Ziemons, Eric  ;  Université de Liège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field
Publication date :
05 January 2018
Journal title :
Journal of Pharmaceutical and Biomedical Analysis
ISSN :
0731-7085
eISSN :
1873-264X
Publisher :
Elsevier
Volume :
147
Pages :
458-472
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 June 2017

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