Article (Scientific journals)
ABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.
Canaani, Jonathan; Savani, Bipin N.; Labopin, Myriam et al.
2017In American Journal of Hematology, 93, p. 246-253
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Abstract :
[en] ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibility affects outcome in MMURD transplantation for acute myeloid leukemia (AML) patients is unknown. We evaluated 1,013 AML patients who underwent MMURD transplantation between 2005 and 2014. Engraftment rates were comparable between ABO matched and mismatched patients, as were relapse incidence [34%; 95% confidence interval (CI), 28-39; for ABO matched vs. 36%; 95% CI, 32-40; for ABO mismatched; P = .32], and nonrelapse mortality (28%; 95% CI, 23-33; for ABO matched vs. 25%; 95% CI, 21-29; for ABO mismatched; P = .2). Three year survival was 40% for ABO matched and 43% for ABO mismatched patients (P = .35), Leukemia free survival rates were also comparable between groups (37%; 95% CI, 32-43; for ABO matched vs. 38%; 95% CI, 33-42; for ABO mismatched; P = .87). Incidence of grade II-IV acute graft versus host disease was marginally lower in patients with major ABO mismatching (Hazard ratio of 0.7, 95% CI, 0.5-1; P = .049]. ABO incompatibility probably has no significant clinical implications in MMURD transplantation.
Disciplines :
Hematology
Author, co-author :
Canaani, Jonathan
Savani, Bipin N.
Labopin, Myriam
Michallet, Mauricette
Craddock, Charles
Socie, Gerard
Volin, Lisa
Maertens, Johan A.
Crawley, Charles
Blaise, Didier
Ljungman, Per T.
Cornelissen, Jan
Russell, Nigel
Baron, Frédéric  ;  Université de Liège > GIGA-R : Hématologie
Gorin, Norbert
Esteve, Jordi
Ciceri, Fabio
Schmid, Christoph
Giebel, Sebastian
Mohty, Mohamad
Nagler, Arnon
More authors (11 more) Less
Language :
English
Title :
ABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.
Publication date :
2017
Journal title :
American Journal of Hematology
ISSN :
0361-8609
eISSN :
1096-8652
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Volume :
93
Pages :
246-253
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2017 Wiley Periodicals, Inc.
Available on ORBi :
since 27 June 2017

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