Article (Scientific journals)
Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.
Baron, Frédéric; Ruggeri, Annalisa; Beohou, Eric et al.
2017In Journal of Hematology and Oncology, 10 (1), p. 128
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Keywords :
ALL; AML; Double; Reduced-intensity; Single; Transplantation; UCB; Unrelated cord blood
Abstract :
[en] BACKGROUND: The feasibility of cord blood transplantation (CBT) in adults is limited by the relatively low number of hematopoietic stem/progenitor cells contained in one single CB unit. The infusion of two CB units from different partially HLA-matched donors (double CBT) is frequently performed in patients who lack a sufficiently rich single CB unit. METHODS: We compared CBT outcomes in patients given single or double CBT following reduced-intensity conditioning (RIC) in a retrospective multicenter registry-based study. Inclusion criteria included adult (>/=18 years) patients, acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL), complete remission (CR) at the time of transplantation, first single (with a cryopreserved TNC >/= 2.5 x 107/kg) or double CBT between 2004 and 2014, and RIC conditioning. RESULTS: Data from 534 patients with AML (n = 408) or ALL (n = 126) receiving a first single (n = 172) or double (n = 362) CBT were included in the analyses. In univariate analysis, in comparison to patients transplanted with a single CB, double CB recipients had a similar incidence of neutrophil engraftment but a suggestion for a higher incidence of grade II-IV acute GVHD (36 versus 28%, P = 0.08). In multivariate analyses, in comparison to single CBT recipients, double CBT patients had a comparable incidence of relapse (HR = 0.9, P = 0.5) and of nonrelapse mortality (HR = 0.8, P = 0.3), as well as comparable overall (HR = 0.8, P = 0.17), leukemia-free (HR = 0.8, P = 0.2) and GVHD-free, relapse-free (HR = 1.0, P = 0.3) survival. CONCLUSIONS: These data failed to demonstrate better transplantation outcomes in adult patients receiving double CBT in comparison to those receiving single CBT with adequate TNC after RIC.
Disciplines :
Oncology
Author, co-author :
Baron, Frédéric  ;  Université de Liège > GIGA-R : Hématologie
Ruggeri, Annalisa
Beohou, Eric
Labopin, Myriam
Mohty, Mohamad
Blaise, Didier
Cornelissen, Jan J.
Chevallier, Patrice
Sanz, Guillermo
Petersen, Eefke
Savani, Bipin N.
Gluckman, Eliane
Nagler, Arnon
More authors (3 more) Less
Language :
English
Title :
Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT.
Publication date :
2017
Journal title :
Journal of Hematology and Oncology
eISSN :
1756-8722
Publisher :
BioMed Central, London, United Kingdom
Volume :
10
Issue :
1
Pages :
128
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 June 2017

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