[en] Aims
To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender.
Methods and results
A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets. The lowest expected values of LV strains and twist calculated as ± 1.96 standard deviations from the mean were −16.7% in men and −17.8% in women for longitudinal strain, −22.3% and −23.6% for circumferential strain, 20.6% and 21.5% for radial strain, and 2.2 degrees and 1.9 degrees for twist, respectively. In multivariable analysis, longitudinal strain decreased with age whereas the opposite occurred with circumferential and radial strain. Male gender was associated with lower strain for longitudinal, circumferential, and radial strain. Inter-vendor differences were observed for circumferential and radial strain despite the use of vendor-independent software. Importantly, no intervendor differences were noted in longitudinal strain.
Conclusion
The NORRE study provides contemporary, applicable 2D echocardiographic reference ranges for LV longitudinal, radial, and circumferential strain. Our data highlight the importance of age- and gender-specific reference values for LV strain.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Sugimoto, T; Université de Liège - ULiège > Cardiologie
DULGHERU, Raluca Elena ; Centre Hospitalier Universitaire de Liège - CHU > Service de cardiologie
BERNARD, Anne-Catherine ; Centre Hospitalier Universitaire de Liège - CHU > Service de cardiologie
Ilardi, Federica; Université de Liège - ULiège > Cardiologie
Contu, L; Université de Liège - ULiège > Cardiologie
Addetia, K; University of Chicago > Medicine
Caballero, L; Hospital Clinico Universitario Virgen de la Arrixaca > Cardiologie
Akhaladze, N; JO ANN Medical Center > Echocardiography
Athanassopoulos, George; Onassis Cardiac Surgery Cente > Noninvasive Diagnostics
Barone, D; S. Andrea Hospital > Cardiologie
Baroni, M; Fondazione Toscana ‘G.Monasterio’—Ospedale Del Cuore > Laboratorio Di Ecocardiografia Adulti
Cardim, Nuno; Hospital da Luz > Echocardiography
Hagendorff, Andreas; University of Leipzig > Cardiology-Angiology
Hristova, K; University National Heart Hospital > Noninvasive Functional Diagnostic and Imaging
Lopez, T; La Paz University Hospital > Cardiology
de la Morena, G; Hospital Clinico Universitario Virgen de la Arrixaca > Cardiologie
Popescu, Bogdan Alexandru; Carol Davila’ University of Medicine and Pharmacy—Euroecolab, Institute of Cardiovascular Diseases
MOONEN, Marie ; Centre Hospitalier Universitaire de Liège - CHU > Service de cardiologie
Penicka, M; OLV-Clinic > Cardiovascular Center Aalst
Ozyigit, T; Kardiyoloji Bölümü > VKV Amerikan Hastanesi
Carbonero, JDR; Hospital de Cruces > Echocardiography
van de Veire, N; AZ Maria Middelares Gent > Echocardiography
von Bardeleben, RS; Universitätsmedizin of the Johannes Gutenberg-University Mainz > Cardiologie
Vinereanu, D; University of Medicine and Pharmacy Carol Davila > Cardiovascular Research
Zamorano, JL; University Alcala, Hospital Ramón y Cajal
Go, YY; Université de Liège - ULiège > Cardiology
Rosca, M; Carol Davila’ University of Medicine and Pharmacy—Euroecolab, Institute of Cardiovascular Diseases
Calin, A; Carol Davila’ University of Medicine and Pharmacy—Euroecolab, Institute of Cardiovascular Diseases
Magne, Julien; CHU Dupuytren, Limoges
Cosyns, Bernard; Universitair ziekenhuis Brussel > CHVZ (Centrum voor Hart en Vaatziekten)
MARCHETTA, Stella ; Centre Hospitalier Universitaire de Liège - CHU > Service de cardiologie
Donal, Erwan; Université Rennes 1 > Cardiologie
Habib, G; La Timone Hospital > Cardiologie
Galderisi, Maurizio; Federico II University Hospital > Advanced Biomedical Sciences
Badano, LP; University of Padova > Cardiac, Thoracic and Vascular Sciences
Lang, RM; University of Chicago > Medicine
Lancellotti, Patrizio ; Université de Liège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie
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