Article (Scientific journals)
The Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission.
Zeippen, Caroline; Javaux, Justine; Xiao, Xue et al.
2017In Journal of Virology, 91 (13)
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Keywords :
gammaherpesvirus; glycoprotein; release; transmission
Abstract :
[en] Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and in vitro, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection but is poorly released from vaginal epithelial cells and fails to pass from the female to the male genital tract during sexual contact. Thus, we show that the regulation of virion binding is a key component of spontaneous gammaherpesvirus transmission.IMPORTANCE Gammaherpesviruses are responsible for many important diseases in both animals and humans. Some important aspects of their life cycle are still poorly understood. Key among these is viral transmission. Here we show that the major envelope glycoprotein of murid herpesvirus 4 functions not in entry or dissemination but in virion release to allow sexual transmission to new hosts.
Disciplines :
Microbiology
Author, co-author :
Zeippen, Caroline ;  Université de Liège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Javaux, Justine
Xiao, Xue ;  Université de Liège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Ledecq, Marina
Mast, Jan
Farnir, Frédéric  ;  Université de Liège > Département des productions animales (DPA) > Biostatistiques et bioinformatique appliquées aux sc. vétér.
Vanderplasschen, Alain ;  Université de Liège > Immunologie et vaccinologie
Stevenson, Philip
Gillet, Laurent  ;  Université de Liège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Language :
English
Title :
The Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission.
Publication date :
2017
Journal title :
Journal of Virology
ISSN :
0022-538X
eISSN :
1098-5514
Publisher :
American Society for Microbiology, Washington, United States - District of Columbia
Volume :
91
Issue :
13
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2017 American Society for Microbiology.
Available on ORBi :
since 22 June 2017

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