Reference : Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/21205
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
English
Peigneux, Philippe mailto [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Fuchs, Sonia [> > > >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Perrin, Fabien [> > > >]
Reggers, Jean [Centre Hospitalier Universitaire de Liège - CHU > > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E >]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Del Fiore, Guy [> > > >]
Aerts, Joël mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
28-Oct-2004
Neuron
Cell Press
44
3
535-545
Yes (verified by ORBi)
International
0896-6273
Cambridge
[en] Brain Mapping ; Hippocampus/physiology ; Positron-Emission Tomography/methods ; Humans ; Sleep/physiology ; Memory/physiology
[en] In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of spatial memories. Here, using regional cerebral blood flow measurements, we show that, in humans, hippocampal areas that are activated during route learning in a virtual town are likewise activated during subsequent slow wave sleep. Most importantly, we found that the amount of hippocampal activity expressed during slow wave sleep positively correlates with the improvement of performance in route retrieval on the next day. These findings suggest that learning-dependent modulation in hippocampal activity during human sleep reflects the offline processing of recent episodic and spatial memory traces, which eventually leads to the plastic changes underlying the subsequent improvement in performance.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/21205
10.1016/j.neuron.2004.10.007
http://www.neuron.org/

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