Reference : Learned material content and acquisition level modulate cerebral reactivation during pos...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/21204
Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep
English
Peigneux, Philippe mailto [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Fuchs, Sonia [> > > >]
Destrebecqz, Arnaud [> > > >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Delbeuck, Xavier [> > > >]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Aerts, Joël mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Del Fiore, Guy [> > > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Cleeremans, Axel [> > > >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Sep-2003
NeuroImage
Academic Press Inc Elsevier Science
20
1
125-134
Yes (verified by ORBi)
International
1053-8119
San Diego
[en] We have previously shown that several brain areas are activated both during sequence learning at wake and during subsequent rapid-eye-movements (REM) sleep (Nat. Neurosci. 3 (2000) 831-836), suggesting that REM sleep participates in the reprocessing of recent memory traces in humans. However, the nature of the reprocessed information remains open. Here, we show that regional cerebral reactivation during posttraining REM sleep is not merely related to the acquisition of basic visuomotor skills during prior practice of the serial reaction time task, but rather to the implicit acquisition of the probabilistic rules that defined stimulus sequences. Moreover, functional connections between the reactivated cuneus and the striatum-the latter being critical for implicit sequence learning-are reinforced during REM sleep after practice on a probabilistic rather than on a random sequence of stimuli. Our results therefore support the hypothesis that REM sleep is deeply involved in the reprocessing and optimization of the high-order information contained in the material to be learned. In addition, we show that the level of acquisition of probabilistic rules attained prior to sleep is correlated to the increase in regional cerebral blood flow during subsequent REM sleep. This suggests that posttraining cerebral reactivation is modulated by the strength of the memory traces developed during the learning episode. Our data provide the first experimental evidence for a link between behavioral performance and cerebral reactivation during REM sleep. (C) 2003 Elsevier Inc. All rights reserved.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/21204
10.1016/S1053-8119(03)00278-7
http://www.elsevier.com/wps/find/journaldescription.cws_home/622925/description#description

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