Article (Scientific journals)
Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.
Debacq, Christophe; Gillet, Nicolas; Asquith, Becca et al.
2006In Journal of Virology, 80 (19), p. 9710-9719
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Keywords :
B-cell homeostasis; Bovine Leukemia Virus; Peripheral blood circulation; Virology; Microbiology; Sheep; Lymphoid tissues; Infection; Deltaretrovirus; Homéostasie des cellules B; Virus de la leucémie bovine; Circulation sanguine périphérique; Tissus lymphoïdes; Delta rétrovirus; Virologie; Microbiologie; Mouton
Abstract :
[en] The size of a lymphocyte population is primarily determined by a dynamic equilibrium between cell proliferation and death. Hence, lymphocyte recirculation between the peripheral blood and lymphoid tissues is a key determinant in the maintenance of cell homeostasis. Insights into these mechanisms can be gathered from large-animal models, where lymphatic cannulation from individual lymph nodes is possible. In this study, we assessed in vivo lymphocyte trafficking in bovine leukemia virus (BLV)-infected sheep. With a carboxyfluorescein diacetate succinimidyl ester labeling technique, we demonstrate that the dynamics of lymphocyte recirculation is unaltered but that accelerated proliferation in the lymphoid tissues is compensated for by increased death in the peripheral blood cell population. Lymphocyte homeostasis is thus maintained by biphasic kinetics in two distinct tissues, emphasizing a very dynamic process during BLV infection.
Disciplines :
Agriculture & agronomy
Biochemistry, biophysics & molecular biology
Oncology
Author, co-author :
Debacq, Christophe;  Université de Liège - ULg/ FNRS Fusagx > Gembloux Agro-Bio Tech > Biologie Moléculaire et Cellulaire
Gillet, Nicolas ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Asquith, Becca;  Imperial College, London > Department of immunology
Sanchez-Alcaraz, Maria theresa;  University of Toronto - U of T > Department of Medical Genetics and Microbiology
Florins, Arnaud-Francois ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Boxus, Mathieu ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Schwartz-Cornil, Isabelle;  Institut Scientifique de Recherche Agronomique - INRA, Jouy en Josas > U 892
Bonneau, Michel;  Institut Scientifique de Recherche Agronomique - INRA, Jouy-en-josas > U 892
Jean, Geneviève ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Kerkhofs, Pierre;  Veterinary and Agrochemical research centre, Belgium > Department of Virology
Hay, Jack;  University of Toronto - U of T > Department of Immunology
Thewis, André ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Kettmann, Richard ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research
More authors (4 more) Less
Language :
English
Title :
Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.
Publication date :
2006
Journal title :
Journal of Virology
ISSN :
0022-538X
eISSN :
1098-5514
Publisher :
American Society for Microbiology (ASM), Washington, United States - District of Columbia
Volume :
80
Issue :
19
Pages :
9710-9719
9710-9719
Peer reviewed :
Peer Reviewed verified by ORBi
Additional URL :
Funders :
Belgian Foundation against the Cancer
the 6th Framework program INCA project of the European Union
the Bekales Foundation
the Fortis Bank Assurance
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
the Leverhulme Trust
Interuniversity attraction Poles Programme
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