Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
Foguenne, Jacques; Di Stefano; Giet, Olivieret al.
[en] Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34+ cells.
Disciplines :
Hematology
Author, co-author :
Foguenne, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Secteur assurance qualité
Di Stefano
Giet, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Thérapie cellulaire
Beguin, Yves ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale
Gothot, André ; Université de Liège - ULiège > Hématologie biologique et immuno hématologie
Language :
English
Title :
Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
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