ORBi: Foguenne Jacques - Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice

Reference : Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Hematology
	To cite this reference:	http://hdl.handle.net/2268/21181

Title :	Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
Language :	English
Author, co-author :	Foguenne, Jacques [Centre Hospitalier Universitaire de Liège - CHU > > Secteur assurance qualité >]
	Di Stefano [> >]
	Giet, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Thérapie cellulaire >]
	Beguin, Yves [Université de Liège - ULg > Département des sciences cliniques > Hématologie - Oncologie médicale >]
	Gothot, André [Université de Liège - ULg > > Hématologie biologique et immuno hématologie >]
Publication date :	2009
Journal title :	Haematologica
Publisher :	Ferrata Storti Foundation
Volume :	94
Pages :	185-194
Audience :	International
ISSN :	0390-6078
e-ISSN :	1592-8721
City :	Pavia
Country :	Italy
Keywords :	[en] stem cells ; hematopoiesis ; cell trafficking
Abstract :	[en] Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34+ cells.
Permalink :	http://hdl.handle.net/2268/21181

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