Article (Scientific journals)
Unguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata.
Campos, Pierre-Eric; Wolfender, Jean-Luc; Quieroz, Emerson F. et al.
2017In Journal of Natural Products, 80, p. 1404-1410
Peer Reviewed verified by ORBi
 

Files


Full Text
campos2017.pdf
Publisher postprint (1.35 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four pentacyclic alkaloids, ptilomycalins E-H (2-5), along with four known compounds: crambescidin 800 (6) and crambescidin 359 (7), crambescidic acid (8), and fromiamycalin (9). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E (2) and the mixture of the new ptilomycalins G (4) and H (5) showed promising cytotoxicity against KB cells with IC50 values of 0.85 and 0.92 μM, respectively. Ptilomycalin F (3) and fromiamycalin (9) exhibited promising activity against Plasmodium falciparum with IC50 values of 0.23 and 0.24 μM, respectively
Research center :
L.C.S.N.S.A
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Campos, Pierre-Eric;  Université de La Réunion > Faculté des Sciences et Technologies > Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments > docteur
Wolfender, Jean-Luc;  University of lausanne > EPGL > school of pharmaceutical sciences
Quieroz, Emerson F.;  unversity of lausanne > EPGL > school of pharmaceutical sciences
Marcourt, Laurence;  university of lausanne > EPGL > School of pharmaceutical Sicences
Al-Mourabit, Ali;  Université Paris-Sud 11 > CNRS UPR 2301 > Institut de chimie des substances naturelles
Frederich, Michel  ;  Université de Liège > Département de pharmacie > Pharmacognosie
Bordignon, Annélise ;  Université de Liège > Département de pharmacie > Pharmacognosie
De Voogd, Nicole;  Naturalis Biodiversity Center
Illien, Bertrand;  Université de La réunion > fFaculté des scicences et technologies > Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments
Gauvin-Bialeki, Anne;  Université de la Réunion > Faculté des Sciences et Technologies > Laboratoire des Substances Naturelles et des Sciences des Aliments
Language :
English
Title :
Unguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata.
Publication date :
10 April 2017
Journal title :
Journal of Natural Products
ISSN :
0163-3864
eISSN :
1520-6025
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
80
Pages :
1404-1410
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
BIOMOL-TCN
Funders :
European Commission and the Regional Concil of Reunion Island
Available on ORBi :
since 09 June 2017

Statistics


Number of views
124 (5 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
35
Scopus citations®
without self-citations
31
OpenCitations
 
30

Bibliography


Similar publications



Contact ORBi