Activation-induced cell death in T lymphocytes from multiple sclerosis patients.

[en] Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation.

Disciplines :

Neurology

Author, co-author :

Perez Boza, Jennifer ; Université de Liège - ULiège > Doct. sc. (bioch., biol. mol.&cell., bioinf.&mod.-Bologne)

Language :

English

Title :

Activation-induced cell death in T lymphocytes from multiple sclerosis patients.

Publication date :

2014

Journal title :

Journal of Neuroimmunology

ISSN :

0165-5728

eISSN :

1872-8421

Publisher :

Elsevier Science, Amsterdam, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.ncbi.nlm.nih.gov/pubmed/?term=24793898

Available on ORBi :

since 07 June 2017

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