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pH-sensitive micellar systems for controlled drug delivery: synthesis and structural characterization by small-angle neutron scattering
Joset, Arnaud; Jérôme, Christine; Brulet, Annie et al.
2009Journées Rencontres des Jeunes Chimistes 6eme édition
 

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Keywords :
self-assembly in solution; micelle; small angle neutron scattering (SANS)
Abstract :
[en] The aim of the project is the preparation of micellar nanocarriers made of biocompatibles copolymers and their structural analysis by Small Angle Neutron Scattering (SANS). These micelles could be used in drug delivery applications to fight cancer1. The hydrophobic polycaprolactone (PCL) core is intended to incorporate the drug. The corona of hydrophilic polyethylene oxide (PEO) stabilizes the nanocarriers with respect to the plasma proteins. The pH in the neighborhood of the tumoral cells is lower than in the healthy cells. We incorporated a pH-sensitive sequence of poly(2-vinylpyridine) (P2VP). As a result, these micelles are expected to deliver their drug near the cancerous cells without affecting the healthy cells. When the pH is acidic, the P2VP is protonated and the chains are repulsive. The micellar size is then larger than in basic pH, when the P2VP is precipitated on the PCL core. We prepared PCL65-b-P2VP31 / PCL65-b-PEO114 and PCL32-b-P2VP52 / PCL36-b-PEO114 50:50 mixtures of diblocks copolymers. The resulting mixed micelles are analyzed by SANS. We developed a theoretical model with a spherical water-free PCL core. The PEO corona is described as consisting of gaussian chains with a thickness estimated as twice the chain gyration radius, Rg. We propose two alternatives for handling the P2VP zone. The P2VP molecules are either assumed to be Gaussian chains or they fill a shell of thickness L with possible water penetration.The fitting of the models to the experimental scattering cross sections leads to important structural parameters like the aggregation number, the core radius, the gyration radius and the thickness of the P2VP shell.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Joset, Arnaud ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) and Molecular Dynamics Laboratory
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Brulet, Annie;  Laboratoire Léon brillouin, (CNRS-CEA), CEA Saclay, Gif sur Yvette, France
Leyh, Bernard  ;  Université de Liège - ULiège > Department of Chemistry > Molecular Dynamics Laboratory
Language :
English
Title :
pH-sensitive micellar systems for controlled drug delivery: synthesis and structural characterization by small-angle neutron scattering
Publication date :
March 2009
Event name :
Journées Rencontres des Jeunes Chimistes 6eme édition
Event organizer :
Comité des Jeunes Chimistes de la Société Royale de Chimie (SRC)
Event place :
Namur, Belgium
Event date :
19/03/2009 - 20/03/2009
Available on ORBi :
since 04 September 2009

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