Article (Scientific journals)
Presence of γ-aminobutyric acid transporter mRNA in interneurons and principal cells of rat hippocampus
Frahm, Christiane; Engel, Dominique; Piechotta, Antje et al.
2000In Neuroscience Letters, 288 (3), p. 175-178
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Keywords :
g-Aminobutyric acid uptake; inhibition; interneurons; in situ hybridization; hippocampus
Abstract :
[en] After release, neurotransmitters are removed from the extracellular space by high-af®nity uptake. Speci®c sodiumdependent transporters serve this function for the inhibitory transmitter g-aminobutyric acid (GABA). However, it is largely unknown to which proportion GABA is taken up by GABAergic interneurons, glia cells or principal neurons. We analyzed the distribution of mRNA for the main GABA-transporter subtype in the hippocampus, GAT-1, in adult rats. Most interneurons were strongly stained for GAT-1 mRNA, indicating re-uptake by the GABA-releasing cells. Surprisingly, prominent signals for GAT-1 were also found throughout the principal cell layers (granule and pyramidal cells). These data indicate that GABA transporters may be present in non-GABAergic projection cells of the rat hippocampus which contribute to the clearance of GABA from the extracellular space
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Frahm, Christiane
Engel, Dominique  ;  Université de Liège > Département des sciences biomédicales et précliniques > Pharmacologie
Piechotta, Antje
Heinemann, Uwe
Draguhn, Andreas
Language :
English
Title :
Presence of γ-aminobutyric acid transporter mRNA in interneurons and principal cells of rat hippocampus
Publication date :
2000
Journal title :
Neuroscience Letters
ISSN :
0304-3940
eISSN :
1872-7972
Publisher :
Elsevier, Limerick, Ireland
Volume :
288
Issue :
3
Pages :
175-178
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
SFB 515/B1
Funders :
DFG - Deutsche Forschungsgemeinschaft [DE]
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