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Poster (Scientific congresses and symposiums)
Thiol-ene reaction: an efficient tool to design polyphosphoester-based drug delivery systems
Riva, Raphaël; Vanslambrouck, Stéphanie; Ergül, Zeynep et al.
2017Belgian Polymer Group (BPG) Annual Meeting
 

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Keywords :
biomaterial; nanomedicine; polyphosphate; polymer functionalization; thiol ene reaction
Abstract :
[en] Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromolecules, polyphosphoesters (PPE) are appealing polymers for biomedical applications. In contrast to polyesters, PPE properties and functionality are easily tuned via the chemical nature of the lateral chains. To enhance the drug loading capacity of PPE-based micelles used as carriers for the delivery of poorly soluble drugs, an efficient strategy to increase the lipophilicity of the PPE block of polyethylene oxide (PEO)-b-PPE amphiphilic copolymers has been investigated. A PEO-b-PPE copolymer bearing pendant vinyl groups along the PPE block was synthesized and then modified by thiol-ene click reaction with thiols bearing either a long linear alkyl chain (dodecyl) or a tocopherol moiety. Ketoconazole was used as model for hydrophobic drugs. Comparison of the loading contents and release profiles with PEO-b-PPE bearing shorter pendant groups is presented evidencing the key role of the structure of the pendant group on the PPE backbone. Finally, the low cytotoxicity of these novel PEO-b-PPE copolymers was also demonstrated. The tocopherol derivative was evidenced as particularly promising for drug delivery systems.
Research center :
Center for Education and Research on Macromolecules (CERM)
CESAM Complex and Entangled Systems from Atoms to Materials (CESAM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Riva, Raphaël ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Vanslambrouck, Stéphanie ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Ergül, Zeynep ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Clément, Benoit;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Préat, Véronique;  Université catholique de Louvain (UCL), Brussels, Louvain Drug Research Institute, Pharmaceutics and Drug Deliv (LDRI)
Gagliardi, Mick;  University of Maastricht, Faculty of Health, Medicine and Life Science, Department of Physiology
Molin, Daniel G. M.;  University of Maastricht, Faculty of Health, Medicine and Life Science, Department of Physiology
Koole, Léo H.;  University of Maastricht, Faculty of Health, Medicine and Life Science, Department of Biomedical Engineering/Biomaterials Sciences
Lecomte, Philippe  ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine  ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Thiol-ene reaction: an efficient tool to design polyphosphoester-based drug delivery systems
Publication date :
04 May 2017
Event name :
Belgian Polymer Group (BPG) Annual Meeting
Event place :
Houffalize, Belgium
Event date :
04/05/2017 - 05/05/2017
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
The Interreg project BioiMedics
Commentary :
This poster was presented by Raphaël Riva
Available on ORBi :
since 23 May 2017

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