Article (Scientific journals)
Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.
Laguesse, Sophie; Close, Pierre; Van Hees, Laura et al.
2017In Frontiers in Cellular Neuroscience, 11, p. 122
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Keywords :
HDAC6; acetylation; cerebral cortex; connexin-43; elongator
Abstract :
[en] The Elongator complex is required for proper development of the cerebral cortex. Interfering with its activity in vivo delays the migration of postmitotic projection neurons, at least through a defective alpha-tubulin acetylation. However, this complex is already expressed by cortical progenitors where it may regulate the early steps of migration by targeting additional proteins. Here we report that connexin-43 (Cx43), which is strongly expressed by cortical progenitors and whose depletion impairs projection neuron migration, requires Elongator expression for its proper acetylation. Indeed, we show that Cx43 acetylation is reduced in the cortex of Elp3cKO embryos, as well as in a neuroblastoma cell line depleted of Elp1 expression, suggesting that Cx43 acetylation requires Elongator in different cellular contexts. Moreover, we show that histones deacetylase 6 (HDAC6) is a deacetylase of Cx43. Finally, we report that acetylation of Cx43 regulates its membrane distribution in apical progenitors of the cerebral cortex.
Research center :
Giga-Neurosciences et GIGA Molecular Biology of Diseases
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Laguesse, Sophie  ;  Université de Liège > Giga - Neurosciences
Close, Pierre  ;  Université de Liège > Département de pharmacie > Chimie médicale
Van Hees, Laura ;  Université de Liège > Giga - Neurosciences
Chariot, Alain ;  Université de Liège > Département de pharmacie > Chimie médicale
Malgrange, Brigitte  ;  Université de Liège > GIGA - Neurosciences
Nguyen, Laurent  ;  Université de Liège > GIGA - Neurosciences
Language :
English
Title :
Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.
Publication date :
2017
Journal title :
Frontiers in Cellular Neuroscience
eISSN :
1662-5102
Publisher :
Frontiers Media S.A., Switzerland
Volume :
11
Pages :
122
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 22 May 2017

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