Reference : Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exace...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/210719
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
English
Toussaint, Marie [> >]
Jackson, David J. [> >]
Swieboda, Dawid [> >]
Guedan, Anabel [> >]
Tsourouktsoglou, Theodora-Dorita [> >]
Ching, Yee Man [> >]
Radermecker, Coraline mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Makrinioti, Heidi [> >]
Aniscenko, Julia [> >]
Edwards, Michael R. [> >]
Solari, Roberto [> >]
Farnir, Frédéric mailto [Université de Liège > Département des productions animales (DPA) > Biostatistiques et bioinformatique appliquées aux sc. vétér. >]
Papayannopoulos, Venizelos [> >]
Bureau, Fabrice mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Marichal, Thomas mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire >]
Johnston, Sebastian L. [> >]
2017
Nature Medicine
Yes (verified by ORBi)
International
1078-8956
1546-170X
United States
[en] Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
http://hdl.handle.net/2268/210719
10.1038/nm.4332

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