[en] The administration of 6g per day of temocillin by continuous infusion in critically patients with severe nosocomial pneumonia allows a penetration ratio, measured by the ELF/plasma ratio of AUCs, of 0.14 and 0.57 and a mean (± SE) ELF concentration , in mg/L, of 9.8 ± 1.3 and 9.8 ± 1.6 for total and free drug, respectively. Standard error of AUCs should be calculated by the Bootstrap method and Monte Carlo simulations should be performed for subsequent PK/PD analysis.
Disciplines :
Immunology & infectious disease
Author, co-author :
VISEE, Clotilde ; Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne
LAYIOS, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > Service des soins intensifs généraux
MISTRETTA, Virginie ; Centre Hospitalier Universitaire de Liège - CHU > Service de toxicologie
MAES, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico économiques (SIME)
VAN BAMBEKE, Françoise; Université catholique de Louvain, Brussels, Belgium > Pharmacologie cellulaire et moléculaire > Louvain Drug Research Institute
FRIPPIAT, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne
Language :
English
Title :
Epithelial lining fluid penetration of temocillin administered by continuous infusion in critically ill patients with nosocomial pneumonia
Publication date :
23 April 2017
Event name :
27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
Event place :
Vienne, Austria
Event date :
du 22 avril 2017 au 25 avril 2017
Audience :
International
References of the abstract :
Abstract N° 2207, E-poster N° EP0353; disponibles sur le site de l'ESCMID (eLibrary)
Funders :
Fonds d‘Investissement pour la Recherche Scientifique de l‘hôpital universitaire de Liège (F.I.R.S).
