Article (Scientific journals)
UV Visible Spectrophotometric Determination of the Quality of Antiretroviral Drugs Distributed in Kinshasa
Ntambwe Kamangu, Erick; Mbinze Kindenge, Jérémie; Mingu M., Arnold et al.
2017In Open Acces Library Journal
Peer reviewed
 

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Keywords :
Spectrophotometry; UV-Visible; ARV; Kinshasa
Abstract :
[en] Background: Antiretrovirals (ARVs) are the molecules used in the fight against infection by the Human Immunodeficiency Virus (HIV). Their main objective is to stop the virus from replicating and thus allow the immune system to recover. In 2001, the program to fight against HIV/AIDS United Nations (UNAIDS) and its partners has decided to strengthen the pharmaceutical channel and improve access to good quality care. Thus ARV quality control is recommended. Objective: The objective of this work was to monitor the quality of ARVs distributed in Kinshasa. Methodology: In this work, UV-visible spectrophotometry is used for the analysis of ARVs presented in simple form distributed in the city of Kinshasa. Results: The results of this work show that the stated and analyzed ARVs contain active ingredients; there is no placebo. Ten percent of these ARVs are non-compliant with regard to dosing of the active test. Conclusion: These results confirm the need to control these drugs to protect patients from adverse consequences related to their poor quality.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Ntambwe Kamangu, Erick;  University of Kinshasa > Laboratory of Molecular Biochemistry, Department of Basic Sciences, Faculty of Medicine
Mbinze Kindenge, Jérémie ;  Université de Liège - ULiège > chercheur libre médecine
Mingu M., Arnold;  University of Kinshasa > Laboratory of Analytical Pharmaceutical, Department of Galenic and Drugs Analysis, Faculty of Pharmaceutical Sciences
Bolavie Bolande, Jacquie;  Institute of Research in Science of Health - Kinshasa > Laboratory Service
Mvumbi Lelo, Georges;  University of Kinshasa > Laboratory of Molecular Biochemistry, Department of Basic Sciences, Faculty of Medicine
Lunganza Kalala, Richard;  University of Kinshasa > Laboratory of Molecular Biochemistry, Department of Basic Sciences, Faculty of Medicine
Mesiah Kahunu, Gauthier;  University of Kinshasa > Unit of Clinical Pharmacology, Department of Pharmacology, Faculties of Medicine and Pharmaceutical Sciences
Lusakibanza Manzo, Mariano ;  Université de Liège - ULiège > Master spéc. pédago. univ. & ens. sup.
Mavar Tayey Mbay, Jean;  University of Kinshasa > Laboratory of Analytical Pharmaceutical, Department of Galenic and Drugs Analysis, Faculty of Pharmaceutical Sciences
Marini Djang'Eing'A, Roland ;  Université de Liège > Département de pharmacie > Chimie analytique
Language :
English
Title :
UV Visible Spectrophotometric Determination of the Quality of Antiretroviral Drugs Distributed in Kinshasa
Publication date :
15 February 2017
Journal title :
Open Acces Library Journal
Peer reviewed :
Peer reviewed
Available on ORBi :
since 10 May 2017

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