Adipsic diabetes insipidus revealing a bifocal intracranial germinoma

[en] Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. We describe the diagnostic procedures and the three-year follow-up of this patient. Management of intracranial germ-cell tumors is made complex by the wide range of histological features. Although germinomas have a generally better prognosis than most nongerminomatous tumors, they can have severe or even life-threatening presentations. Adipsic diabetes insipidus is one such severe presentation and its rarity can make it difficult to recognize and manage. Awareness of this potential entity is therefore important for clinical practice. Le diabète insipide adipsique est une des rares complications des tumeurs intracrâniennes. Il associe une baisse de la sécrétion d’hormone antidiurétique à une perte de la sensation de soif et ilsignale souvent la présence d’une lésion qui atteint ou envahit l’hypothalamus. Nous présentons le cas d’une patiente avec un germinome intracrânien bifocal diagnostiqué devant un tableau de diabète insipide adipsique. À notre connaissance, il s’agit du premier cas de la littérature d’un diabète insipide révélant un germinome intracrânien. La prise en charge des tumeurs germinales intracrâniennes est complexe du fait des phénotypes histologiques divers. Bien que les germinomes ont généralement un meilleur pronostic que les tumeurs non-germinomateuses, ils peuvent avoir des présentations sévères. Le diabète insipide adipsique est une de ces présentations sévères et sa rareté peut rendre son diagnostic et sa prise en charge difficiles. La reconnaissance de cette entité potentielle est, dès lors, importante pour la pratique clinique

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

KREUTZ, Julie ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic

Potorac, Iulia ; Université de Liège - ULiège > Doct. sc. médicales (Bologne)

LUTTERI, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Service de chimie clinique

GENNIGENS, Christine ; Centre Hospitalier Universitaire de Liège - CHU > Service d'oncologie médicale

MARTIN, Didier ; Centre Hospitalier Universitaire de Liège - CHU > Service de neurochirurgie

Daly, Adrian ; Université de Liège > Département des sciences cliniques > Endocrinologie

BONNEVILLE, Jean-François ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic

TSHIBANDA, Luaba ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic

BECKERS, Albert ; Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique

Language :

English

Title :

Adipsic diabetes insipidus revealing a bifocal intracranial germinoma

Alternative titles :

[en] Un cas de diabète insipide adipsique révélant un germinome intracrânien bifocal

Publication date :

05 May 2017

Journal title :

Annales d'Endocrinologie

ISSN :

0003-4266

Publisher :

Masson, Moulineaux Cedex 9, France

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://doi.org/10.1016/j.ando.2016.10.005

Available on ORBi :

since 06 May 2017

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