Article (Scientific journals)
Genetic architecture of declarative memory: implications for complex illnesses.
Bearden, Carrie E.; Karlsgodt, Katherine H.; Bachman, Peter et al.
2012In Neuroscientist, 18 (5), p. 516-32
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Keywords :
Alzheimer Disease/genetics/psychology; Animals; Brain/physiology; Genetic Association Studies/methods/trends; Heredity/genetics/physiology; Humans; Individuality; Memory, Long-Term/physiology; Models, Neurological; Neural Pathways/physiology; Neurofibromatosis 1/genetics/psychology; Schizophrenia/genetics; Schizophrenic Psychology
Abstract :
[en] Why do memory abilities vary so greatly across individuals and cognitive domains? Although memory functions are highly heritable, what exactly is being genetically transmitted? Here we review evidence for the contribution of both common and partially independent inheritance of distinct aspects of memory function. We begin by discussing the assessment of long-term memory and its underlying neural and molecular basis. We then consider evidence for both specialist and generalist genes underlying individual variability in memory, indicating that carving memory into distinct subcomponents may yield important information regarding its genetic architecture. And finally we review evidence from both complex and single-gene disorders, which provide insight into the molecular mechanisms underlying the genetic basis of human memory function.
Disciplines :
Neurosciences & behavior
Author, co-author :
Bearden, Carrie E.
Karlsgodt, Katherine H.
Bachman, Peter
van Erp, Theo G. M.
Winkler, Anderson ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
Glahn, David C.
Language :
English
Title :
Genetic architecture of declarative memory: implications for complex illnesses.
Publication date :
2012
Journal title :
Neuroscientist
ISSN :
1073-8584
eISSN :
1089-4098
Publisher :
SAGE Science Press, United States - California
Volume :
18
Issue :
5
Pages :
516-32
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2017

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