AChEI; SSRI; acetylcholine; citalopram; functional connectivity; galantamine; psychopharmacology; resting state fMRI; resting state network; serotonin
Abstract :
[en] Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired per subject during this randomized, double blind, placebo-controlled, crossover study. Within-group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P < 0.05, FWE-corrected) using a non-parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self-referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects. Hum Brain Mapp 38:308-325, 2017. (c) 2016 Wiley Periodicals, Inc.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Klaassens, Bernadet L.
Rombouts, Serge A. R. B.
Winkler, Anderson ; Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
van Gorsel, Helene C.
van der Grond, Jeroen
van Gerven, Joop M. A.
Language :
English
Title :
Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.
Publication date :
2017
Journal title :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Volume :
38
Issue :
1
Pages :
308-325
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
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