Shared genetic variance between obesity and white matter integrity in Mexican Americans.

[en] Obesity is a chronic metabolic disorder that may also lead to reduced white matter integrity, potentially due to shared genetic risk factors. Genetic correlation analyses were conducted in a large cohort of Mexican American families in San Antonio (N = 761, 58% females, ages 18-81 years; 41.3 +/- 14.5) from the Genetics of Brain Structure and Function Study. Shared genetic variance was calculated between measures of adiposity [(body mass index (BMI; kg/m(2)) and waist circumference (WC; in)] and whole-brain and regional measurements of cerebral white matter integrity (fractional anisotropy). Whole-brain average and regional fractional anisotropy values for 10 major white matter tracts were calculated from high angular resolution diffusion tensor imaging data (DTI; 1.7 x 1.7 x 3 mm; 55 directions). Additive genetic factors explained intersubject variance in BMI (heritability, h (2) = 0.58), WC (h (2) = 0.57), and FA (h (2) = 0.49). FA shared significant portions of genetic variance with BMI in the genu (rhoG = -0.25), body (rhoG = -0.30), and splenium (rhoG = -0.26) of the corpus callosum, internal capsule (rhoG = -0.29), and thalamic radiation (rhoG = -0.31) (all p's = 0.043). The strongest evidence of shared variance was between BMI/WC and FA in the superior fronto-occipital fasciculus (rhoG = -0.39, p = 0.020; rhoG = -0.39, p = 0.030), which highlights region-specific variation in neural correlates of obesity. This may suggest that increase in obesity and reduced white matter integrity share common genetic risk factors.

Disciplines :

Human health sciences: Multidisciplinary, general & others
Genetics & genetic processes

Author, co-author :

Spieker, Elena A.

Kochunov, Peter

Rowland, Laura M.

Sprooten, Emma

Winkler, Anderson ; Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.

Olvera, Rene L.

Almasy, Laura

Duggirala, Ravi

Fox, Peter T.

Blangero, John

Glahn, David C.

Curran, Joanne E.

Language :

English

Title :

Shared genetic variance between obesity and white matter integrity in Mexican Americans.

Publication date :

2015

Journal title :

Frontiers in Genetics

eISSN :

1664-8021

Publisher :

Frontiers Media S.A., Switzerland

Volume :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 May 2017

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91 (2 by ULiège)

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