Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression.

Adult; Aged; Aging/physiology; Brain/pathology; Brain Mapping; Depressive Disorder, Major/pathology; Diffusion Tensor Imaging; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Nerve Fibers, Myelinated/pathology; Schizophrenia/pathology

Abstract :

[en] BACKGROUND: Elevated rate of aging-related biological and functional decline, termed "accelerated aging," is reported in patients with schizophrenia (SCZ) and major depressive disorder (MDD). We used diffusion tensor imaging derived fractional anisotropy (FA) as a biomarker of aging-related decline in white matter (WM) integrity to test the hypotheses of accelerated aging in SCZ and MDD. METHODS: The SCZ cohort comprised 58 SCZ patients and 60 controls (aged 20-60 years). The MDD cohort comprised 136 MDD patients and 351 controls (aged 20-79 years). The main outcome measures were the diagnosis-by-age interaction on whole-brain-averaged WM FA values and FA values from 12 major WM tracts. RESULTS: Diagnosis-by-age interaction for the whole-brain average FA was significant for the SCZ (p = .04) but not the MDD (p = .80) cohort. Diagnosis-by-age interaction was nominally significant (p<.05) for five WM tracts for SCZ and for none of the tracts in the MDD cohort. Tract-specific heterochronicity of the onset of age-related decline in SCZ demonstrated strong negative correlations with the age-of-peak myelination and the rates of age-related decline obtained from normative sample (r =-.61 and-.80, p<.05, respectively). No such trends existed for MDD cohort. CONCLUSIONS: Cerebral WM showed accelerated aging in SCZ but not in MDD, suggesting some difference in the pathophysiology underlying their WM aging changes. Tract-specific heterochronicity of WM development modulated presentation of accelerated aging in SCZ: WM tracts that matured later in life appeared more sensitive to the pathophysiology of SCZ and demonstrated more susceptibility to disorder-related accelerated decline in FA values with age. This trend was not observed in MDD cohort.

Disciplines :

Psychiatry

Author, co-author :

Kochunov, Peter

Glahn, David C.

Rowland, Laura M.

Olvera, Rene L.

Winkler, Anderson ; Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.

Yang, Yi-Hong

Sampath, Hemalatha

Carpenter, Will T.

Duggirala, Ravindranath

Curran, Joanne

Blangero, John

Hong, L. Elliot

Language :

English

Title :

Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression.

Publication date :

2013

Journal title :

Biological Psychiatry

ISSN :

0006-3223

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

482-91

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 03 May 2017

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