P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.

[en] BACKGROUND AND PURPOSE: We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity. METHODS: The subject pool consisted of 369 (219F; aged 28-85, average = 47.1 +/- 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter thickness, fractional anisotropy of cerebral white matter, and the volume of hyperintensive WM lesions. RESULTS: From the 13 gene expressions, significant phenotypic correlations were only found for the P- and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-selectin expression were driven by shared genetic factors, while the correlations with L-selectin expression were due to shared environmental effects. CONCLUSION: This study demonstrated that P-selectin expression shared a significant variance with measurements of cerebral integrity and posits elevated P-selectin expression levels as a potential risk factor of hypertension-related cerebral atrophy.

Disciplines :

Genetics & genetic processes
Neurology

Author, co-author :

Kochunov, P.

Glahn, D. C.

Hong, L. E.

Lancaster, J.

Curran, J. E.

Johnson, M. P.

Winkler, Anderson ; Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.

Holcomb, H. H.

Kent, J. W. Jr

Mitchell, B.

More authors (9 more)

Language :

English

Title :

P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.

Publication date :

2012

Journal title :

Frontiers in Genetics

eISSN :

1664-8021

Publisher :

Frontiers Media S.A., Switzerland

Volume :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 03 May 2017

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