Heterogeneous incidence and propagation of spreading depolarizations.

[en] Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically, apparently not respecting the anatomic, synaptic, functional, or vascular architecture of the brain. However, there is evidence that spreading depolar- izations are not truly concentric, isotropic, or homogeneous, either in space or in time. Here we present evidence from KCl-induced spreading depolarizations, in mouse and rat, in vivo and in vitro, showing the great variability that these depolarizations can exhibit. This variability can help inform the mechanistic understanding of spreading depolarizations, and it has implications for their phenomenology in neurologic disease.

Disciplines :

Neurology

Author, co-author :

Kaufmann, Dan; University of Utah, Salt Lake City, UT, USA > Department of Neurology

Theriot, Jeremy

Zyuzin, Jekaterina

Service, Austin

Chang, Joshua

Tang, Tanye

Bogdanov, Vladimir

Multon, Sylvie ; Université de Liège > Département des sciences biomédicales et précliniques > Histologie

Schoenen, Jean

Ju, Sungtaek

Brennan, KC

Language :

English

Title :

Heterogeneous incidence and propagation of spreading depolarizations.

Publication date :

2017

Journal title :

Journal of Cerebral Blood Flow and Metabolism

ISSN :

0271-678X

eISSN :

1559-7016

Publisher :

SAGE, Thousand Oaks, United States - California

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 17 March 2017

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