Article (Scientific journals)
Photoreversibility and biocompatibility of polydimethylsiloxane-coumarin as adjustable intraocular lens material
Jellali, Rachid; Bertrand, Virginie; Alexandre, Michaël et al.
2017In Macromolecular Bioscience, p. 1600495
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Keywords :
biomaterial; implant; intraocular lens
Abstract :
[en] Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomed- ical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a photoreversible PDMS-coumarin network, whose shape and properties can be adjusted postoperatively in a noninvasive manner, is developed. The synthesis of PDMS-cou- marin is achieved by amidation of a coumarin acid chloride derivative with amine-function- alized PDMSs. Under exposure of λ > 300 nm, these polymers can be cured by dimerization of coumarin. The cured polymers can be uncrosslinked via photocleavage of cyclobutane dimers upon illumination at λ < 290 nm. The diffusion of linear PDMSs in a crosslinked network and the controlled shape modification are studied, which demonstrate that these polymers are good candidates for adjustable IOL application. IOL disks prepared from these materials show high hydrophobicity and good transparency. In vitro cytotoxicity, lens epithelial cell adhesion assays, and rabbit host reaction against implanted disks demonstrate the biocompatibility of the polymer.
Research center :
Center for Education and Research on Macromolecules (CERM)
CESAM Complex and Entangled Systems from Atoms to Materials (CESAM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Jellali, Rachid ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Bertrand, Virginie ;  University of Liège (ULg), GIGA-R, Laboratory of Mammalian Cell Culture
Alexandre, Michaël ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Rosière, Nancy ;  University of Liège (ULg), GIGA-R, Laboratory of Mammalian Cell Culture
Grauwels, Magda ;  University of Liège (ULg), Département Clinique des Animaux de Compagnie et des Équidés
De Pauw-Gillet, Marie-Claire ;  University of Liège (ULg), GIGA-R, Laboratory of Mammalian Cell Culture
Jérôme, Christine  ;  University of Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM), Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Photoreversibility and biocompatibility of polydimethylsiloxane-coumarin as adjustable intraocular lens material
Publication date :
2017
Journal title :
Macromolecular Bioscience
ISSN :
1616-5187
eISSN :
1616-5195
Publisher :
John Wiley & Sons, United Kingdom
Pages :
1600495
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
The Walloon Region in the frame of the SmartIOL and Lionel projects
Available on ORBi :
since 16 March 2017

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