Article (Scientific journals)
Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-alpha Receptor Delays Behavioral Fever in Fish.
Rakus, Krzysztof; Ronsmans, Maygane; Forlenza, Maria et al.
2017In Cell Host and Microbe, 21 (2), p. 244-253
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Keywords :
behavioral fever; cyprinid herpesvirus 3; fever; herpesvirus; host-virus interactions; immune evasion mechanisms; innate immunity; pathogen-host-environment interplay; tumor necrosis factor alpha; viral decoy receptor for cytokine
Abstract :
[en] Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term "behavioral fever." We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24 degrees C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24 degrees C-32 degrees C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-alpha, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-alpha neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Rakus, Krzysztof
Ronsmans, Maygane
Forlenza, Maria
Boutier, Maxime ;  Université de Liège > Immunologie et vaccinologie
Piazzon, M. Carla
Jazowiecka-Rakus, Joanna
Gatherer, Derek
Athanasiadis, Alekos
Farnir, Frédéric  ;  Université de Liège > Département des productions animales (DPA) > Biostatistiques et bioinformatique appliquées aux sc. vétér.
Davison, Andrew J.
Boudinot, Pierre
Michiels, Thomas
Wiegertjes, Geert F.
Vanderplasschen, Alain ;  Université de Liège > Immunologie et vaccinologie
More authors (4 more) Less
Language :
English
Title :
Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-alpha Receptor Delays Behavioral Fever in Fish.
Publication date :
2017
Journal title :
Cell Host and Microbe
ISSN :
1931-3128
eISSN :
1934-6069
Publisher :
Cell Press, Cambridge, United States - Massachusetts
Volume :
21
Issue :
2
Pages :
244-253
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
Available on ORBi :
since 08 March 2017

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