Article (Scientific journals)
Long-term evolution and predictive factors of mild inflammatory bowel disease.
REENAERS, Catherine; Pirard, C.; VAN KEMSEKE, Catherine et al.
2016In Scandinavian Journal of Gastroenterology, 51 (6), p. 712-9
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Keywords :
Adolescent; Adult; Age Factors; Aged; Child; Colitis, Ulcerative/diagnosis/therapy; Crohn Disease/diagnosis/therapy; Databases, Factual; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Severity of Illness Index; Young Adult; Benign evolution; complication; mild IBD; predictive factor
Abstract :
[en] BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are potentially progressive diseases. Few data are available on the prevalence and the factors associated with mild inflammatory bowel diseases (IBD). AIM: Our aim was to assess the natural history of mild CD and mild UC and to identify predictive factors of mild evolution over the long term. METHODS: Retrospective study of IBD patients registered in the database of the university hospital CHU of Liege, Belgium. Mild CD was defined as an inflammatory luminal disease (no stricture, abdominal or perianal fistulae) requiring no immunomodulator (IM), anti-TNF and no surgery. Mild UC was defined as no requirement for IM, anti-TNF and no colectomy. RESULTS: Four hundred and seventy-three CD and 189 UC were included (median follow-up: 13 and 11 years respectively). At 1 year, 147 patients had mild CD. At 5 years and the maximum follow-up, 56% and 13% patients still had mild CD, respectively. At 1 year, 142 patients had mild UC. At 5 years and the maximum follow-up, 72% and 44% still had a mild UC, respectively. Factors associated with long-term mild CD and UC were older age at diagnosis and absence of corticosteroids in the first year. In UC proctitis location was associated with mild UC. CONCLUSIONS: In this cohort, 90% of CD patients and 3/4 of UC with mild disease at 1 year lost their mild disease status over time. An old age at diagnosis was predictive of the persistence of a mild CD and UC.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
REENAERS, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
Pirard, C.
VAN KEMSEKE, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
LATOUR, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
Belaiche, Jacques ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
Louis, Edouard  ;  Université de Liège > Département des sciences cliniques > Hépato-gastroentérologie
Language :
English
Title :
Long-term evolution and predictive factors of mild inflammatory bowel disease.
Publication date :
2016
Journal title :
Scandinavian Journal of Gastroenterology
ISSN :
0036-5521
eISSN :
1502-7708
Publisher :
Taylor & Francis, United Kingdom
Volume :
51
Issue :
6
Pages :
712-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 March 2017

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