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Study Protocol: Effect of prenatal wheel-running exercise (before and during gestation) on cocaine psychomotor sensitization expressed in the offspring in periadolescent females and males C57BL/6J mice
Lespine, Louis-Ferdinand; Plenevaux, Alain; Tirelli, Ezio
2017
 

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Keywords :
animal model of addiction; cocaine; prenatal exercise; behavioural sensitization; C57BL/6J mice; offspring
Abstract :
[en] The present study principally aims at determining to which extent prenatal exercise (before and during gestation) could affect the initiation (establishment) and the expression of psychomotor sensitization induced by a representative dose of cocaine in young female and male mice. More specifically, we will assess cocaine-induced acute psychomotor-activating effects, psychomotor sensitization developing over 9 daily sessions (daily peritoneal injections of cocaine or saline) and the long-term expression of the sensitized response (30 days after the last sensitizing injection) in C57BL/6J mice born from mothers housed with or without a running wheel before and during gestation. Based on literature and on our prior results, the mice born from exercised mothers are expected to show significantly reduced levels of cocaine responsiveness in comparison with the control mice (born from unexercised mothers).
Disciplines :
Neurosciences & behavior
Author, co-author :
Lespine, Louis-Ferdinand ;  Université de Liège > Département de Psychologie > Neuroscience comportementale et psychopharmacologie expér.
Plenevaux, Alain  ;  Université de Liège > Département de chimie (sciences) > Département de chimie (sciences)
Tirelli, Ezio ;  Université de Liège > Département de Psychologie > Neuroscience comportementale et psychopharmacologie expér.
Language :
English
Title :
Study Protocol: Effect of prenatal wheel-running exercise (before and during gestation) on cocaine psychomotor sensitization expressed in the offspring in periadolescent females and males C57BL/6J mice
Publication date :
2017
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 26 February 2017

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