ORBi: Bruyère Olivier - Interest of biochemical markers of bone turnover for long-term prediction of new vertebral fracture in postmenopausal osteoporotic women

Reference : Interest of biochemical markers of bone turnover for long-term prediction of new vertebr...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics) Human health sciences : Geriatrics Social & behavioral sciences, psychology : Sociology & social sciences
	To cite this reference:	http://hdl.handle.net/2268/2072

Title :	Interest of biochemical markers of bone turnover for long-term prediction of new vertebral fracture in postmenopausal osteoporotic women
Language :	English
Author, co-author :	Bruyère, Olivier [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
	Collette, Julien [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
	Delmas, Pierre [> > > >]
	Rouillon, Alain [> > > >]
	Roux, Christian [> > > >]
	Seidel, Laurence [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
	Richy, Florent [> > > >]
	Reginster, Jean-Yves [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
Publication date :	25-Apr-2003
Journal title :	Maturitas
Publisher :	Elsevier Sci Ireland Ltd
Volume :	44
Issue/season :	4
Pages :	259-265
Audience :	International
ISSN :	0378-5122
City :	Clare
Keywords :	[en] osteoporosis ; bone turnover markers ; vertebral fracture ; bone mineral density
Abstract :	[en] Objective: To analyse the interest of baseline levels and short-term (3-months) changes in serum osteocalcin (BGP), serum bone-specific alkaline phosphatase (BALP) and urinary C-telopeptide of type I collagen/creatinine ratio (U-TX) to predict 3-years changes in bone mineral density (BMD) and spinal deformity index (SDI) in postmenopausal osteoporotic women. Methods: Data were derived from a cohort of 603 osteoporotic women corresponding to the placebo arm of a 3-years prospective, double-blind study. Results: Baseline values of BALP, BGP and U-CTX were negatively and significantly correlated with baseline spinal BMD. Significant correlations were also observed between the changes in BMD observed after 36 months at the spine and baseline BALP (r = 0.20, P = 0.0001), BGP (r = 0.09, P = 0.05) and U-CTX (r = -0.11, P = 0.02). At 3 years, 71 women (15.9%) showed an increase in their SDI, corresponding to the occurrence of at least one new vertebral deformity. Baseline values of the four bone turnover markers (BTM) were not significantly related to the occurrence of new vertebral deformities. However, when considering the changes in the BTM observed after 3-months of follow-up, BGP (P = 0.003) and U-CTX (P = 0.047) were identified as significant predictors of an increase of SDI. The associated odds ratios (95% confidence interval (CI)) were 10.922 (2.218-53.78) for unit changes of log BGP and 1.369 (1.003-1.867) for unit changes of log U-CTX. The relative risk (RR) (IC 95%) of having a new vertebral fracture over 36 months was 0.31 (0.15-0.65) when being in the lowest quartile of 3-months changes in BGP as compared with the highest. Conclusion: We conclude that two sequential measurements of BGP and U-CTX performed at 3-months intervals could be of interest to identify postmenopausal osteoporotic women with the highest risk to present new vertebral deformities. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Permalink :	http://hdl.handle.net/2268/2072

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