Poster (Scientific congresses and symposiums)
INVESTIGATION DE LA QUALITE D’ANTIBIOTIQUES A BASE D'AMOXICILLINE DANS LE CADRE DE LA SURVEILLANCE DU MARCHE OFFICIEL ET PERIPHERIQUE DE QUELQUES VILLES DE LA R.D. CONGO
Kalenda Tshilombo, Nicodème; Ciza Hamuli, Patient; Mavungu Landu, Don Jethro et al.
201712ème Congrès Francophone sur les sciences séparatives et les couplages de AFSEP
 

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Keywords :
Validation; Médicaments de qualité inférieure; Contrôle qualité
Abstract :
[en] Drug counterfeiting is a sad and worrisome reality, especially in developing countries where quality control is not effective and sometimes not existing at all despite political will of governments. The consequences are harmful in particular for substandard medicines that pose more threats to populations in those countries due to their direct negative impact on patients such as failure of medical treatment including development of drug resistance and even death. Socio-economic consequences and negative reputation concerning the pharmaceutical industry are also observed. Unfortunately accurate detailed data on such medicines are not easy to obtain. Most of the time available data are often estimated from case reports or studies carried out in a specific area and during a defined period.Health authorities’ in the Democratic Republic of Congo are trying to identify this scourge by set up several strategies to fight against. One of them is built on the best knowledge of drugs from several horizons through the assessment of their quality to allow appropriate measurement. In this context, we have focused our study towards amoxicillin alone and/or combined with potassium clavulanate since it is one the very used medicines in pediatric medications. The formulations are powder for suspension. Two analytical methods were developed based on the USP monography, applying isocratic liquid chromatography. Prior to their application in routine, we evaluated the suitability of these methods through validation applying the accuracy profile of total error. Since it was planned to transfer the methods to DRC, several operating factors were taken into account namely operator, day and equipment. Interesting results were obtained in terms of trueness (relative biases below than 2.3%), precision (RSD of Intermediate precision below 2.8%), accuracy (beta-expectation tolerance intervals between -6.0% and 3.8%) for the concentration levels of interest. The latter were able to allow monitoring the quality of the two active ingredients here above in the 65 samples from Congolese market. They were collected in Kinshasa, Lubumbashi, Matadi and Kolwezi at official and non-official medicines distributors, in peripheral area. The dramatic results obtained confirm that substandard and counterfeit medicines remain a crucial problem on public health in low-income countries. Appropriate measures are really needed to set up the drug quality improvement.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Kalenda Tshilombo, Nicodème ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Ciza Hamuli, Patient  ;  Université de Liège - ULiège > stage conv. étrangères ou CFB en médecine
Mavungu Landu, Don Jethro ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (paysage)
Mwamba, Pierrot;  Université de lumbabashi
Waffo Tchounga, Christelle  ;  Université de Liège - ULiège
Tidiane, Diallo;  Université de Bamako
Mbinze, Jéremie;  Université de Kinshasa
Hubert, Philippe  ;  Université de Liège > Département de pharmacie > Chimie analytique
Marini Djang'Eing'A, Roland ;  Université de Liège > Département de pharmacie > Chimie analytique
Language :
French
Title :
INVESTIGATION DE LA QUALITE D’ANTIBIOTIQUES A BASE D'AMOXICILLINE DANS LE CADRE DE LA SURVEILLANCE DU MARCHE OFFICIEL ET PERIPHERIQUE DE QUELQUES VILLES DE LA R.D. CONGO
Alternative titles :
[en] QUALITY EVALUATION OF ANTIBIOTICS BASED OF AMOXICILLIN , AS PART OF INVESTIGATION OF THE OFFICIAL AND PERIPHERAL DRUG MARKET IN SOME D.R.CONGO CITIES
Publication date :
March 2017
Event name :
12ème Congrès Francophone sur les sciences séparatives et les couplages de AFSEP
Event organizer :
Association francophone des sciences séparatives (AFSEP)
Event place :
Paris, France
Event date :
du 28 au 30 mars 2017
Audience :
International
Name of the research project :
Développement, validation et transfert de méthodes analytiques génériques pour lutter contre la falsification des médicaments : Application en zones périurbaines - RDC
Funders :
ARES - Académie de Recherche et d'Enseignement Supérieur [BE]
ULiège - Université de Liège [BE]
Available on ORBi :
since 09 February 2017

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