Article (Scientific journals)
Blood Oxygen Binding in Calves with Naturally Occurring Diarrhea
Cambier, Carole; Clerbaux, T.; Moreaux, B. et al.
2001In American Journal of Veterinary Research, 62 (5), p. 799-804
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Abstract :
[en] OBJECTIVE: To assess blood oxygen binding in calves with diarrhea. ANIMALS: 22 dairy and 26 double-muscled calves with diarrhea, 31 healthy dairy calves and 37 healthy double-muscled calves. PROCEDURE: Severity of disease, including the ability of affected calves to stand, was evaluated. Hydration and signs of depression were scored. Venous and arterial blood samples were collected, and 2,3-diphosphoglycerate, ATP, chloride, inorganic phosphate, lactate, pyruvate, total protein, albumin, and hemoglobin concentrations, and Hct, pH, Pco2, and PO2 were determined. Oxygen equilibrium curves (OEC) were constructed under standard conditions, and oxygen extraction ratios were calculated. RESULTS: Recumbent calves of both breed-types were more dehydrated and had more severe signs of depression than ambulatory affected calves. In both breed-types, hemoglobin oxygen affinity was increased in calves with diarrhea, compared with healthy calves, as indicated by a decrease in standard partial oxygen pressure (P50). Diarrhea induced hypocapnia and hypothermia in the most severely affected calves, which counteracted the acidosis-induced right shift in arterial and venous OEC. Arterial and venous P50 were significantly less in double-muscled calves with diarrhea than healthy calves, whereas P50 for affected dairy calves were similar to those of healthy calves. Except in the most severely affected dairy calves, oxygen extraction ratio was significantly less in calves with diarrhea, compared with healthy calves. CONCLUSIONS AND CLINICAL RELEVANCE: Release of oxygen from blood may be impaired in calves with diarrhea, depending on the effect of the disease on certain blood biochemical variables.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Cambier, Carole ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Département de sciences fonctionnelles
Clerbaux, T.
Moreaux, B.
Detry, Benoît ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Beerens, Dominique ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Département de sciences fonctionnelles
Frans, A.
Gustin, Pascal ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie
Language :
English
Title :
Blood Oxygen Binding in Calves with Naturally Occurring Diarrhea
Publication date :
2001
Journal title :
American Journal of Veterinary Research
ISSN :
0002-9645
eISSN :
1943-5681
Publisher :
American Veterinary Medical Association
Volume :
62
Issue :
5
Pages :
799-804
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 January 2017

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