sCD14 is not a bona-fide biomarker of microbial translocation in HIV-1 infected Africans living in Belgium.

[en] OBJECTIVE: To compare microbial translocation and its biomarkers in HIV-1 infected African and Caucasian patients of the Liege AIDS Reference Center. DESIGN: The study is based on a cross-sectional dataset of HIV-infected patients treated at the Liege AIDS Reference Center. Groups of Caucasian and African patients have been randomly selected in order to be identical for sex, age and duration of treatment. METHODS: sCD14, Lipopolysaccharide (LPS), lipopolysaccharide binding protein (LBP) and routine HIV-follow-up parameters were measured on plasma samples. RESULTS: High values of LPS and LBP were observed in both groups of patients without significant difference between them. High values of sCD14 were observed in 53.1% of Caucasians and only in 18.8% of African patients (p = 0.0042). A correlation between LPS and sCD14 was observed in Caucasians but not African patients. CONCLUSION: Our observation suggests that factors not related to microbial translocation are responsible for lower sCD14 value in Africans.

Disciplines :

General & internal medicine

Author, co-author :

DE VOEGHT, Adrien ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'hématologie clinique

Maes, Nathalie

Moutschen, Michel ; Université de Liège - ULiège

Language :

English

Title :

sCD14 is not a bona-fide biomarker of microbial translocation in HIV-1 infected Africans living in Belgium.

Publication date :

27 March 2016

Journal title :

AIDS

ISSN :

0269-9370

eISSN :

1473-5571

Publisher :

Lippincott Williams & Wilkins, United States

Volume :

30 (6)

Pages :

921-4

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 January 2017

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Bibliography

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