Article (Scientific journals)
Outcomes of UCB transplantation are comparable in FLT3+ AML: Results of CIBMTR, eurocord and EBMT collaborative analysis.
Ustun, C.; Giannotti, F.; Zhang, M.-J. et al.
2017In Leukemia, 31, p. 1408-1414
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Keywords :
AML; FLT3; umbilical cord blood HCT
Abstract :
[en] Allogeneic hematopoietic cell transplantation (HCT) from siblings or unrelated donors (URD) during complete remission (CR) may improve leukemia-free survival (LFS) in FLT3+ acute myeloid leukemia (AML) that has poor prognosis due to high relapse rates. Umbilical cord blood (UCB) HCT outcomes are largely unknown in this population. We found that compared with sibling HCT, relapse risks were similar after UCB (n=126), (HR 0.86, P=0.54) and URD (n=91) (HR 0.81, P=0.43). UCB HCT was associated with statistically higher non-relapse mortality compared with sibling HCT (HR 2.32, P=0.02), but not vs URD (HR 1.72, P=0.07). All three cohorts had statistically not significant 3-year LFS: 39% (95% CI 30-47) after UCB, 43% (95% CI 30-54) after sibling, and 50% (95% CI 40-60) after URD. Chronic GVHD rates were significantly lower after UCB compared with either sibling (HR 0.59, P=0.03) or URD (HR 0.49, P=0.001). Adverse factors for LFS included high leukocyte count at diagnosis and HCT during CR2. UCB is a suitable option for adults with FLT3+AML in the absence of an HLA-matched sibling and its immediate availability may be particularly important for FLT3+ AML where early relapse is common thus allowing HCT in CR1 when outcomes are best.Leukemia accepted article preview online, 25 January 2017. doi:10.1038/leu.2017.42.
Disciplines :
Hematology
Author, co-author :
Ustun, C.
Giannotti, F.
Zhang, M.-J.
Wang, H.-L.
Brunstein, C.
Labopin, M.
Rocha, V.
de Lima, M.
Baron, Frédéric  ;  Université de Liège > GIGA-R : Hématologie
Sandmaier, B. M.
Eapen, M.
Gluckman, E.
Nagler, A.
Weisdorf, D. J.
Ruggeri, A.
More authors (5 more) Less
Language :
English
Title :
Outcomes of UCB transplantation are comparable in FLT3+ AML: Results of CIBMTR, eurocord and EBMT collaborative analysis.
Publication date :
2017
Journal title :
Leukemia
ISSN :
0887-6924
eISSN :
1476-5551
Publisher :
Nature Publishing Group, United Kingdom
Volume :
31
Pages :
1408-1414
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 January 2017

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