Transdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.

Sergeant, Camille; Jublanc, Christel; Leclercq, Delphine; Boch, Anne-Laure; Bielle, Franck; Raverot, Gerald; Daly, Adrian; Trouillas, Jacqueline; Villa, Chiara

doi:10.1097/PAS.0000000000000803

Article (Scientific journals)

Transdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.

Sergeant, Camille; Jublanc, Christel; Leclercq, Delphine et al.

2017 • In American Journal of Surgical Pathology

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/205411

DOI
10.1097/PAS.0000000000000803

PubMed
28079577

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Abstract :

[en] Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Sergeant, Camille

Jublanc, Christel

Leclercq, Delphine

Boch, Anne-Laure

Bielle, Franck

Raverot, Gerald

Daly, Adrian ; Université de Liège > Département des sciences cliniques > Endocrinologie

Trouillas, Jacqueline

Villa, Chiara

Language :

English

Title :

Transdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.

Publication date :

2017

Journal title :

American Journal of Surgical Pathology

ISSN :

0147-5185

eISSN :

1532-0979

Publisher :

Lippincott Williams & Wilkins, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 17 January 2017

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