Article (Scientific journals)
Aromatase inhibition rapidly affects in a reversible manner distinct features of birdsong
Alward, Beau A.; de Bournonville, Catherine; Chan, Trevor T. et al.
2016In Scientific Reports, p. 32344
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Keywords :
birdsong; aromatase; estradiol; singing behavior
Abstract :
[en] Recent evidence has implicated steroid hormones, specifically estrogens, in the rapid modulation of cognitive processes. Songbirds have been a useful model system in the study of complex cognitive processes including birdsong, a naturally learned vocal behavior regulated by a discrete steroid-sensitive telencephalic circuitry. Singing behavior is known to be regulated by long-term actions of estrogens but rapid steroid modulation of this behavior has never been examined. We investigated if acute actions of estrogens regulate birdsong in canaries (Serinus canaria). In the morning, male canaries sing within minutes after light onset. Birds were injected with fadrozole, a potent aromatase inhibitor, or vehicle within 2-5 minutes after lights on to implement a within-subjects experimental design. This single injection of fadrozole reduced the motivation to sing as well as song acoustic stereotypy, a measure of consistency over song renditions, on the same day. By the next day, however, all song measures that were affected had returned to baseline. This study indicates that estrogens also act in a rapid fashion to regulate two distinct features of song, a learned vocal behavior.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Alward, Beau A.
de Bournonville, Catherine ;  Université de Liège - ULiège > Neurosciences-Neuroendocrinology
Chan, Trevor T.;  Johns Hopkins University > Department of Psychological and Brain Sciences
Balthazart, Jacques  ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Cornil, Charlotte  ;  Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Ball, Gregory F.;  Johns Hopkins University > Department of Psychological and Brain Sciences
Language :
English
Title :
Aromatase inhibition rapidly affects in a reversible manner distinct features of birdsong
Publication date :
2016
Journal title :
Scientific Reports
eISSN :
2045-2322
Publisher :
Nature Publishing Group, London, United Kingdom
Pages :
32344
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NIH - National Institutes of Health [US-MD]
Belspo (IAP)
Available on ORBi :
since 16 January 2017

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