[en] Forty-eight extracts from 16 common Belgian trees from the Walloon Region forest were evaluated for IN VITRO growth inhibitory activity against the human LoVo colon cancer, PC3 prostate cancer, and U373 glioblastoma cell lines. Our study was performed with the aim of selecting plant candidates in order to later isolate new anticancer compounds from an easily affordable tree material. Extracts from ALNUS GLUTINOSA (stem bark), CARPINUS BETULUS (leaves and stem bark), CASTANEA SATIVA (stem bark), FAGUS SYLVATICA (leaves), ILEX AQUIFOLIUM (leaves), LARIX DECIDUA (leaves), QUERCUS PETRAEA (stem bark), and QUERCUS ROBUR (leaves) showed for the first time potent IN VITRO growth inhibitory activity and could become easily affordable sources of potential new anticancer agents. Root extracts from ROBINIA PSEUDOACACIA, already known for containing cytotoxic lectins, also showed interesting activity.
Cragg G M., Newman D J. Plants as a source of anti-cancer agents. J Ethnopharmacol 2005 100 72-77
da Rocha A B., Lopes R M., Schwartsmann G. Natural products in anticancer therapy. Curr Opin Pharmacol 2001 1 364-369
Tesei A, Rosetti M, Ulivi P, Fabbri F, Medri L, Vannini I, Bolla M, Amadori D, Zoli W. Study of molecular mechanisms of pro-apoptotic activity of NCX 4040, a novel nitric oxide-releasing aspirin, in colon cancer cell lines. J Transl Med 2007 5 52-52
Dumont P, Ingrassia L, Rouzeau S, Ribaucour F, Thomas S, Roland I, Darro F, Lefranc F, Kiss R. The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 2007 9 766-776
Van Quaquebeke E, Mahieu T, Dumont P, Dewelle J, Ribaucour F, Simon G, Sauvage S, Gaussin J F., Tuti J, El Yazidi M, Van Vynckt F, Mijatovic T, Lefranc F, Darro F, Kiss R. 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2, 3-dihydro-1Hbenzo[de]isoquinolin-5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. J Med Chem 2007 50 4122-4134
Van Quaquebeke E, Simon G, Andre A, Dewelle J, El Yazidi M, Bruyneel F, Tuti J, Nacoulma O, Guissou P, Decaestecker C, Braekman J C., Kiss R, Darro F. Identification of a novel cardenolide (2-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses. J Med Chem 2005 48 849-856
Hoog P, Boldron C, Gamez P, Sliedregt-Bol K, Roland I, Pitié M, Kiss R, Meunier B, Reedijk J. New approach for the preparation of efficient DNA cleaving agents: ditopic copper-platinum complexes based on 3-Clip-Phen and cisplatin. J Med Chem 2007 50 3148-3152
Bruggisser R, von Daeniken K, Jundt G, Schaffner W, Tullberg-Reinert H. Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay. Planta Med 2002 68 445-448
Simon G, Dewelle J, Nacoulma O, Guissou P, Kiss R, Daloze D, Braekman J C. Cytotoxic pentacyclic triterpenes from Combretum nigricans. Fitoterapia 2003 74 339-344
Salmoun M, Braekman J C., Ranarivelo Y, Rasamoelisendra R, Ralambomanana D, Dewelle J, Darro F, Kiss R. New calamene sesquiterpenes from Tarena madagascarensis. Nat Prod Res 2007 21 111-120
Salmoun M, Braekman J C., Dewelle J, Darro F, Kiss R, De Voogd N J., Van Soest R W. New terpenoids from two Indonesian marine sponges. Nat Prod Res 2007 21 149-155
Pusztai A, Bardocz S, Ewen S W. Uses of plant lectins in bioscience and biomedicine. Front Biosci 2008 13 1130-1140
Goun E A., Petrichenko V M., Solodnikov S U., Suhinina T V., Kline M A., Cunningham G, Nguyen C, Miles H. Anticancer and antithrombin activity of Russian plants. J Ethnopharmacol 2002 81 337-342 (Pubitemid 34786318)
Lefranc F, Mijatovic T, Kondo Y, Sauvage S, Roland I, Krstic D, Vasic V, Gailly P, Kondo S, Blanco G, Kiss R. Targeting the alpha-1 subunit of the sodium pump (the Na+/K+-ATPase) to combat glioblastoma cells. Neurosurgery 2008 62 211-222
Lefranc F, Facchini V, Kiss R. Pro-autophagic drugs: A novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. Oncologist 2007 12 1395-1403
Lefranc F, Ingrassia L, Kiss R. Targeting autophagy: do patents reveal a therapeutic potential? Expert Opin Ther Patents 2008 18 1-7
Moine C, Krausz P, Chaleix V, Sainte-Catherine O, Kraemer M, Gloaguen V. Structural characterization and cytotoxic properties of a 4-O- methylglucuronoxylan from Castanea sativa. J Nat Prod 2007 70 60-66
Barbat A, Gloaguen V, Moine C, Sainte-Catherine O, Kraemer M, Rogniaux H, Ropartz D, Krausz P. Structural characterization and cytotoxic properties of a 4-O-methylglucuronoxylan from Castanea sativa. 2. Evidence of a structure-activity relationship. J Nat Prod 2008 71 1404-1409
Valimaa A L., Honkalampi-Hamalainen U, Pietarinen S, Willför S, Holmbom B, von Wright A. Antimicrobial and cytotoxic knotwood extracts and related pure compounds and their effects on food-associated microorganisms. Int J Food Microbiol 2007 115 235-243
Tian F, McLaughlin J L. Bioactive flavonoids from the black locust tree, Robinia pseudoacacia. Pharm Biol 2000 38 229-234
