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The somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-like Growth Factor 1 axis in immunoregulation and immunosenescence
Bodart, Gwennaëlle; Farhat, Khalil; Charlet-Renard, Jeanne de Chantal et al.
2017In Savino, Wilson; Guaraldi, Federica (Eds.) Endocrine Immunology
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Keywords :
GHRH; GH; IGF1; Immunomodulation; Immunosenescence
Abstract :
[en] Most scientific reports debate the thymotropic and immuno-stimulating properties of the somato- trope growth hormone-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor (IGF)-1 axis, but there is still some disagreement about the physiological role of this axis in basal conditions. Moreover, some authors have hypothesized that the physiological role of the somato- trope axis only appears in stressful conditions (such as sepsis or infective and inflammatory diseases). This chapter will provide an extended overview of the expression of the components (signals and receptors) of the somatotrope axis and their properties on cells of the innate and adaptive immune system. It will also summarize some clinical studies suggesting a benefit for a short-term GH treat- ment in acute immunodeficiencies, and the importance of GH supplementation in adult GH defi- ciency. A new transgenic mouse model, the hypothalamic GHRH-deficient (Ghrh–/–) mouse, which exhibits a severe deficiency of the somatotrope axis, will be presented since it will be of great help in further deciphering the regulation by the GHRH/GH/IGF-1 axis on both immune development and function. Finally, we will discuss the implication of aging-related somatopause in relation to the general context of Immunosenescence.
Research center :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Disciplines :
Immunology & infectious disease
Endocrinology, metabolism & nutrition
Author, co-author :
Bodart, Gwennaëlle ;  Université de Liège > Centre d'immunologie
Farhat, Khalil;  Université de Liège - ULiège > Centre d'Immunologie
Charlet-Renard, Jeanne de Chantal ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique
Salvatori, Roberto
Geenen, Vincent ;  Université de Liège > Centre d'immunologie
Martens, Henri ;  Université de Liège > Centre d'immunologie
Language :
English
Title :
The somatotrope Growth Hormone-Releasing Hormone/Growth Hormone/Insulin-like Growth Factor 1 axis in immunoregulation and immunosenescence
Publication date :
2017
Main work title :
Endocrine Immunology
Editor :
Savino, Wilson
Guaraldi, Federica
Publisher :
Karger, Basel, Switzerland
Collection name :
Frontiers in Hormone Research
Pages :
147-159
Peer reviewed :
Peer reviewed
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Léon Fredericq [BE]
ARC Somasthym
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