Article (Scientific journals)
Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture
Ferrari, S.; Reginster, Jean-Yves; Brandi, M.L. et al.
2016In Archives of Osteoporosis, 11, p. 37
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Keywords :
Osteoporosis; TReatment; DMB; Bone strength; Surgical treatment
Abstract :
[en] Summary: This review provides a critical analysis of currently available approaches to increase bone mass, structure and strength through drug therapy and of possible direct intraosseous interventions for the management of patients at imminent risk of hip fracture. Purpose : Osteoporotic hip fractures represent a particularly high burden in morbidity-, mortality- and health care-related costs. There are challenges and unmet needs in the early prevention of hip fractures, opening the perspective of new developments for the management of osteoporotic patients at imminent and/or at very high risk of hip fracture. Amongst them, preventive surgical intervention needs to be considered. Methods: A European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)/International Osteoporosis Foundation (IOF) working group reviewed the presently available intervention modalities including preventive surgical options for hip fragility. This paper represents a summary of the discussions. Results: Prevention of hip fracture is currently based on regular physical activity; prevention of falls; correction of nutritional deficiencies, including vitamin D repletion; and pharmacological intervention. However, efficacy of these various measures to reduce hip fractures is at most 50% and may need months or years before becoming effective. To face the challenges of early prevention of hip fractures for osteoporotic patients at imminent and/or at very high risk of hip fracture, preventive surgical intervention needs further investigation. Conclusion: Preventive surgical intervention needs to be appraised for osteoporotic patients at imminent and/or at very high risk of hip fracture.
Disciplines :
General & internal medicine
Author, co-author :
Ferrari, S.
Reginster, Jean-Yves  ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Brandi, M.L.
Kanis, J.A.
Devogelaer, J.P.
Kaufmann, J.P.
Feron, J.M.
Kurth, A.
Rizzoli, R.
Language :
English
Title :
Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture
Publication date :
2016
Journal title :
Archives of Osteoporosis
ISSN :
1862-3522
eISSN :
1862-3514
Publisher :
Springer, Germany
Volume :
11
Pages :
37
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 December 2016

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