[en] About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège Inserm U1066
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Karim, Reatul ; Université de Liège > Département de pharmacie > Pharmacie galénique
Palazzo, Claudio ; Université de Liège > Département de pharmacie > Département de pharmacie
Laloy, Julie; Namur Nanosafety Centre, NTHC, University of Namur, Belgium
Lepeltier, Elise; Inserm U1066, IBS-CHU, University of Angers, France
Delvigne, Anne-Sophie; Namur Nanosafety Centre, NTHC, University of Namur, Belgium
Dogne, Jean-Michel; Namur Nanosafety Centre, NTHC, University of Namur, Belgium
Evrard, Brigitte ; Université de Liège > Département de pharmacie > Pharmacie galénique
Passirani, Catherine; Inserm U1066, IBS-CHU, University of Angers, France
Piel, Géraldine ; Université de Liège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
Development and comparison of liposomes and nanocapsules as injectable nanocarriers for poorly aqueous soluble drugs
Publication date :
December 2016
Event name :
Journées annuelles SFNano, Paris 2016
Event organizer :
Société Française de Nanomédecine - French Society for Nanomedicine
