Reference : ERK2 activation in arteriolar and venular murine thrombosis: platelet receptor GPIb v...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/20385
ERK2 activation in arteriolar and venular murine thrombosis: platelet receptor GPIb vs. P2X.
English
Oury, Cécile mailto [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
Daenens, Kim [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
Hu, Hu [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
Toth-Zsamboki, Emese [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
Bryckaert, Marijke [Hopital Lariboisière Paris > > U689 INSERM > >]
Hoylaerts, Marc F [Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB > >]
2006
Journal of Thrombosis and Haemostasis [=JTH]
Blackwell Publishing
Yes (verified by ORBi)
International
1538-7933
1538-7836
Oxford
United Kingdom
[en] Thrombosis ; mouse models ; signaling pathway
[en] The functional significance of extracellular signal-regulated kinase 2 (ERK2) activation was investigated during shear induced human platelet aggregation (SIPA) in vitro and during shear controlled thrombosis in vivo in intestinal arterioles and venules of wild type (WT) and transgenic (TG) mice with platelet-specific overexpression of human P2X(1) (TG). The conclusions are that P2X(1) and ERK2 both participate in shear stress controlled thrombosis, but ERK2 activation is initiated predominantly via GPIb-VWF interactions.
http://hdl.handle.net/2268/20385

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