Article (Scientific journals)
AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
Conteduca, Giuseppina
2016In Oncotarget
Peer Reviewed verified by ORBi
 

Files


Full Text
AIRE MAGE.pdf
Author postprint (2.23 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
AIRE; MAGE; mTEC
Abstract :
[en] AIRE is involved in susceptibility to melanoma perhaps regulating T cell immunity against melanoma antigens (MA). To address this issue, AIRE and MAGEB2 expressions were measured by real time PCR in medullary thymic epithelial cells (mTECs) from two strains of C57BL/6 mice bearing either T or C allelic variant of the rs1800522 AIRE SNP. Moreover, the extent of apoptosis induced by mTECs in MAGEB2-specific T cells and the susceptibility to in vivo melanoma B16F10 cell challenge were compared in the two mouse strains. The C allelic variant, protective in humans against melanoma, induced lower AIRE and MAGEB2 expression in C57BL/6 mouse mTECs than the T allele. Moreover, mTECs expressing the C allelic variant induced lower extent of apoptosis in MAGEB2-specific syngeneic T cells than mTECs bearing the T allelic variant (p < 0.05). Vaccination against MAGEB2 induced higher frequency of MAGEB2-specific CTL and exerted higher protective effect against melanoma development in mice bearing the CC AIRE genotype than in those bearing the TT one (p < 0.05). These findings show that allelic variants of one AIRE SNP may differentially shape the MA-specific T cell repertoire potentially influencing susceptibility to melanoma.
Research center :
CEBR, Centre of Excellence for Biomedical Research
Disciplines :
Oncology
Author, co-author :
Conteduca, Giuseppina ;  Université de Liège > GIGA-R : Hématologie
Language :
English
Title :
AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
Publication date :
22 August 2016
Journal title :
Oncotarget
eISSN :
1949-2553
Publisher :
Impact Journals, Albany, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Immunotherapy anti tumoral
Funders :
MIUR - Ministero dell'Istruzione, dell'Università e della Ricerca [IT]
AIRC - Associazione Italiana per la Ricerca sul Cancro [IT]
Funding number :
PRIN, grant from MIUR
Available on ORBi :
since 21 November 2016

Statistics


Number of views
59 (2 by ULiège)
Number of downloads
119 (0 by ULiège)

Scopus citations®
 
6
Scopus citations®
without self-citations
4
OpenCitations
 
5

Bibliography


Similar publications



Contact ORBi