[en] Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released from plateletdense granules, and ADP is known to contribute to shear-induced platelet aggregation (SIPA). This study shows that ATP also contributes to SIPA. The ATP-gated P2X(1) ion channel induces MLC-mediated cytoskeletal rearrangements that increases platelet degranulation during VWF-triggered platelet activation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Oury, Cécile ; Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB
Sticker, Elsie; Katholieke Universiteit Leuven - KUL > Departement of Molecular and Cellular Medicine > CMVB
Cornelissen, Heidi; Katholieke Universiteit Leuven - KUL > Department of Molecular and Cellular Medicine > CMVB
De Vos, Rita; Katholieke Universiteit Leuven - KUL > Department of Medical Diagnostic Sciences > Morphology and Molecular Pathology Section
Vermylen, Jos; Katholieke Universiteit Leuven - KUL > Department of Molecular and Cellular Medicine > CMVB
Hoylaerts, Marc F; Katholieke Universiteit Leuven - KUL > Department of Molecular and Cellular Medicine > CMVB
Language :
English
Title :
ATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation
Publication date :
2004
Journal title :
Journal of Biological Chemistry
ISSN :
0021-9258
eISSN :
1083-351X
Publisher :
American Society for Biochemistry and Molecular Biology, Baltimore, United States - Maryland
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