Reference : A P2X Ion Channel-triggered NF-{kappa}B Pathway Enhances TNF-{alpha}-induced IL-8 Expres...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/20341
A P2X Ion Channel-triggered NF-{kappa}B Pathway Enhances TNF-{alpha}-induced IL-8 Expression in Airway Epithelial Cells.
English
Theatre, Emilie mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Bours, Vincent mailto [Université de Liège - ULg > > Génétique >]
Oury, Cécile mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine >]
2009
American Journal of Respiratory Cell and Molecular Biology
American Thoracic Society
Yes (verified by ORBi)
International
1044-1549
1535-4989
New York
NY
[en] airway inflammation ; purinergic receptors ; NF-kappaB
[en] Extracellular ATP, acting at P2Y and P2X receptors, has recently been shown to contribute to airway inflammation. Using different epithelial cell models, this study shows that ATP promotes TNF-alpha-elicited IL-8 expression through P2X ion channel-triggered Ca(2+) entry, leading to CaMK-dependent IKK activation and binding of active p65 to IL-8 gene promoter.
http://hdl.handle.net/2268/20341
also: http://hdl.handle.net/2268/21431

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