Poster (Scientific congresses and symposiums)
Pupil size dynamics during prolonged wakefulness reflects the dual interaction of sleep-homeostasis and the circadian timing system and is related to cortical excitability
Van Egroo, Maxime; Cespedes-Ortiz, Cristian; Ly, Julien et al.
201623rd Congress of the European Sleep Research Society
 

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Keywords :
Sleep deprivation; Pupillometry; Cortical excitability
Abstract :
[en] Objective. We sought to characterize daily variations in pupil size as a function of sleep need and circadian phase. We also assessed second-to-second pupil size variability during prolonged wakefulness. Methods. Twenty-two healthy young men (22 y.o. ± 2.6) followed a 29h sleep deprivation protocol under constant routine conditions. On twelve occasions, pupil size was recorded (90 Hz sampling rate) while fixating a dot and suppressing eye blinks. Following automatic eye blink and artefact rejection, mean pupil size and average point to point variation in pupil size data were computed. Data were realigned according to individual dim-light melatonin onset determined based on hourly saliva samples. Results. Preliminary analyses indicate that both mean pupil size and pupil size variability show a main effect of circadian phase (PROC MIXED; n = 20; F11,206 > 4.4, p < 0.001). Post hoc analyses show that mean pupil size and pupil size variability increase up to the evening wake maintenance prior to decreasing until the early morning around the putative sleep promoting zone. Conclusion. These data confirm the pupil size and pupil size variability reflect the dual interaction of sleep homeostasis and the circadian timing system. Further analyses will determine how pupil size dynamics relates to makers of brain function.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Van Egroo, Maxime ;  Université de Liège > Centre de recherches du cyclotron
Cespedes-Ortiz, Cristian ;  Université de Liège - ULiège > Master sc. psycho., à fin.
Ly, Julien
Chellappa, Sarah
Phillips, Christophe  ;  Université de Liège > Centre de recherches du cyclotron
Gaggioni, Giulia ;  Université de Liège > Centre de recherches du cyclotron
Vandewalle, Gilles  ;  Université de Liège > Centre de recherches du cyclotron
Language :
English
Title :
Pupil size dynamics during prolonged wakefulness reflects the dual interaction of sleep-homeostasis and the circadian timing system and is related to cortical excitability
Publication date :
2016
Event name :
23rd Congress of the European Sleep Research Society
Event date :
du 13 septembre 2016 au 16 septembre 2016
Audience :
International
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 10 November 2016

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