Article (Scientific journals)
Impact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites
LAMBERT, France; Bacevic, Miljana; Layrolle, Pierre et al.
2016In Clinical Oral Implants Research
Peer Reviewed verified by ORBi
 

Files


Full Text
18. Lambert_et_al-2016-Clinical_Oral_Implants_Research-2.pdf
Publisher postprint (1.19 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
bone regeneration; hydroxyapatite; osteoconduction; surface characteristics
Abstract :
[en] Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite-based biomaterials (HA) of different origins (natural or synthetic) or manufacturing process in a sinus lift model in rabbits. The secondary objective was to correlate the findings with the physical and topographical characteristics of the biomaterials. Materials and Methods: Two bovine HA manufactured with different processes (bovine hydroxyapatites [BHA] and cuttlebone hydroxyapatite [CBHA]) and a synthetic hydroxyapatite (SHA) sintered at high temperature were characterised with scanning electronic microscopy (SEM) and the measurement of specific surface area (BET). The materials were implanted in a sinus lift model in rabbits; histological and histomorphometric evaluation using non-decalcified sections was performed at 1, 5 and 12 weeks after implantation. Results: The studied biomaterials displayed a different surface topography. The two natural HA displayed significantly higher bone quantities (P = 0.0017; BHA vs. SHA, P = 0.0018 and CBHA vs. SHA, P = 0.033) at 5 and 12 weeks compared to the synthetic one (SHA). Moreover, the osteoconductivity (bone-to-material contact) was significantly higher in the BHA group compared to the two other groups (P = 0.014; BHA vs. SHA, P = 0.023 and BHA vs. CBHA, P = 0.033). Conclusion: HA-based biomaterials from diverse origins and manufacturing processes displayed different topographical characteristics. This may have influenced different regenerated bone architecture observed; more bone was found with natural HA compared to the synthetic one, and significantly higher bone-to-material contacts were found with BHA.
Research center :
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE]
Disciplines :
Dentistry & oral medicine
Author, co-author :
LAMBERT, France ;  Centre Hospitalier Universitaire de Liège - CHU > Service de médecine dentaire
Bacevic, Miljana ;  Université de Liège - ULiège > Form. doct. sc. dentaires
Layrolle, Pierre
Schupbach, Peter
Drion, Pierre ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
ROMPEN, Eric ;  Centre Hospitalier Universitaire de Liège - CHU > Service de médecine dentaire
Language :
English
Title :
Impact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites
Publication date :
22 October 2016
Journal title :
Clinical Oral Implants Research
ISSN :
0905-7161
eISSN :
1600-0501
Publisher :
Munksgaard International Publishers, Copenhagen, Denmark
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 November 2016

Statistics


Number of views
163 (33 by ULiège)
Number of downloads
7 (6 by ULiège)

Scopus citations®
 
23
Scopus citations®
without self-citations
16
OpenCitations
 
18

Bibliography


Similar publications



Contact ORBi